Genetic Determinants of the Association between Osteoarthritis and Psychiatric Disorders

Figure 2

Identification of genes and pathways shared by knee osteoarthritis (OA) and depression. (a) Overlap between gene lists. Each candidate gene is assigned to one spot on the arc of the corresponding gene lists. Dark orange color represents the genes that appear in both lists, and light orange color represents genes that are unique to that gene list. Purple curves link identical genes, and blue curves link genes that have different identities but share an enriched pathway/process (i.e., they represent the functional overlaps among gene lists). (b) The functional relevance of the identified genes, based on reported genes from the GWAS Catalog. The shared genes () were enriched for representation in various diseases or trait-related gene sets using the GENE2FUNC of the FUMA tool. (c) Heatmap of enriched pathways across input gene lists, colored by values, one row per pathway, using a discrete color scale to represent statistical significance. Gray color indicates a lack of significance. (d) Shared MCODE component identified in protein-protein interaction network and the top pathways of the corresponding components, where each node represents a protein with a pie chart encoding its origin (i.e., blue for knee OA and red for depression).