Genetic Determinants of the Association between Osteoarthritis and Psychiatric Disorders

Figure 3

Identification of genes and pathways shared by knee osteoarthritis (OA) and stress-related disorder. (a) Overlap between gene lists. Each candidate gene is assigned to one spot on the arc of the corresponding gene lists. Dark orange color represents the genes that appear in both lists, and light orange color represents genes that are unique to that gene list. Purple curves link identical genes, and blue curves link genes that have different identities but share an enriched pathway/process (i.e., they represent the functional overlaps among gene lists). (b) Heatmap of enriched pathways across input gene lists, colored by values, one row per pathway, using a discrete color scale to represent statistical significance. Gray color indicates a lack of significance. (c) Shared MCODE component identified in protein-protein interaction network and the top pathways of the corresponding components, where each node represents a protein with a pie chart encoding its origin (i.e., red for knee OA and blue for stress-related disorder).