Research Article

Genetic Determinants of the Association between Osteoarthritis and Psychiatric Disorders

Table 1

Longitudinally bidirectional association between osteoarthritis (OA) and psychiatric disorders.

Hip/knee OAHip OAKnee OA
No. of cases (incidencea) in patients/matched individualsHR (95% CI)bNo. of cases (incidencea) in patients/matched individualsHR (95% CI)bNo. of cases (incidencea) in patients/matched individualsHR (95% CI)b

Association of psychiatric disorders with subsequent OA
Any psychiatric disorders5342 (8.567)/16335 (5.281)1.62 (1.57-1.68)1816 (2.791)/7125 (2.259)1.22 (1.16-1.29)3865 (6.102)/10111 (3.23)1.88 (1.80-1.96)
Depression1702 (8.952)/4691 (4.986)1.68 (1.58-1.78)571 (2.871)/2080 (2.17)1.27 (1.15-1.40)1232 (6.368)/2885 (3.031)1.90 (1.77-2.05)
Anxiety1428 (8.471)/4466 (5.394)1.60 (1.50-1.71)469 (2.663)/1964 (2.327)1.16 (1.04-1.29)1059 (6.194)/2751 (3.283)1.89 (1.75-2.04)
Stress-related disorder796 (8.757)/2317 (5.157)1.64 (1.50-1.79)257 (2.702)/1018 (2.223)1.18 (1.02-1.36)587 (6.355)/1426 (3.138)1.97 (1.77-2.19)
Substance misuse1807 (8.309)/5771 (5.298)1.69 (1.58-1.82)642 (2.836)/2496 (2.247)1.34 (1.20-1.50)1280 (5.796)/3578 (3.246)1.94 (1.78-2.11)
Psychotic disorder33 (3.355)/223 (4.544)0.87 (0.56-1.35)10 (1)/103 (2.069)0.68 (0.32-1.44)25 (2.531)/131 (2.642)0.98 (0.57-1.70)
Association of OA with subsequent psychiatric disorders
Any psychiatric disorders2091 (5.907)/5272 (3.034)1.93 (1.83-2.04)558 (4.337)/1846 (2.96)1.43 (1.30-1.58)1544 (6.836)/3438 (3.078)2.23 (2.09-2.38)
Depression702 (1.915)/1518 (0.8359)2.07 (1.88-2.28)193 (1.464)/509 (0.7799)1.78 (1.50-2.12)514 (2.185)/1011 (0.8667)2.24 (1.99-2.51)
Anxiety635 (1.729)/1461 (0.8046)2.11 (1.91-2.33)164 (1.24)/534 (0.8183)1.50 (1.25-1.80)474 (2.011)/930 (0.7972)2.48 (2.20-2.79)
Stress-related disorder340 (0.9198)/663 (0.3651)2.33 (2.03-2.68)88 (0.6624)/231 (0.354)1.75 (1.35-2.27)255 (1.074)/432 (0.3703)2.71 (2.29-3.19)
Substance misuse719 (1.961)/1915 (1.055)1.83 (1.65-2.04)189 (1.431)/691 (1.059)1.23 (1.01-1.50)533 (2.266)/1232 (1.056)2.25 (1.97-2.56)
Psychotic disorder45 (0.1208)/139 (0.07655)1.57 (1.06-2.34)18 (0.1348)/55 (0.08428)1.66 (0.83-3.33)27 (0.1126)/85 (0.07287)1.37 (0.81-2.33)

aPer 1000 person years. bBased on the matched cohort study, HR (95% CI) was derived from the Cox regression models, stratified by matching identifier (birth year, sex), and adjusted for ethnicity, educational attainment, smoking status, drinking status, annual household income, Townsend’s deprivation index (as a continuous variable), body mass index, physical activity, history of other psychiatry disorders, and Charlson’s comorbidity index. Abbreviation: HR: hazard ratios; CI: confidence interval; OA: osteoarthritis.