Genetic Determinants of the Association between Osteoarthritis and Psychiatric Disorders

Table 1

Longitudinally bidirectional association between osteoarthritis (OA) and psychiatric disorders.

	Hip/knee OA		Hip OA		Knee OA
	No. of cases (incidence^a) in patients/matched individuals	HR (95% CI)^b	No. of cases (incidence^a) in patients/matched individuals	HR (95% CI)^b	No. of cases (incidence^a) in patients/matched individuals	HR (95% CI)^b
Association of psychiatric disorders with subsequent OA
Any psychiatric disorders	5342 (8.567)/16335 (5.281)	1.62 (1.57-1.68)	1816 (2.791)/7125 (2.259)	1.22 (1.16-1.29)	3865 (6.102)/10111 (3.23)	1.88 (1.80-1.96)
Depression	1702 (8.952)/4691 (4.986)	1.68 (1.58-1.78)	571 (2.871)/2080 (2.17)	1.27 (1.15-1.40)	1232 (6.368)/2885 (3.031)	1.90 (1.77-2.05)
Anxiety	1428 (8.471)/4466 (5.394)	1.60 (1.50-1.71)	469 (2.663)/1964 (2.327)	1.16 (1.04-1.29)	1059 (6.194)/2751 (3.283)	1.89 (1.75-2.04)
Stress-related disorder	796 (8.757)/2317 (5.157)	1.64 (1.50-1.79)	257 (2.702)/1018 (2.223)	1.18 (1.02-1.36)	587 (6.355)/1426 (3.138)	1.97 (1.77-2.19)
Substance misuse	1807 (8.309)/5771 (5.298)	1.69 (1.58-1.82)	642 (2.836)/2496 (2.247)	1.34 (1.20-1.50)	1280 (5.796)/3578 (3.246)	1.94 (1.78-2.11)
Psychotic disorder	33 (3.355)/223 (4.544)	0.87 (0.56-1.35)	10 (1)/103 (2.069)	0.68 (0.32-1.44)	25 (2.531)/131 (2.642)	0.98 (0.57-1.70)
Association of OA with subsequent psychiatric disorders
Any psychiatric disorders	2091 (5.907)/5272 (3.034)	1.93 (1.83-2.04)	558 (4.337)/1846 (2.96)	1.43 (1.30-1.58)	1544 (6.836)/3438 (3.078)	2.23 (2.09-2.38)
Depression	702 (1.915)/1518 (0.8359)	2.07 (1.88-2.28)	193 (1.464)/509 (0.7799)	1.78 (1.50-2.12)	514 (2.185)/1011 (0.8667)	2.24 (1.99-2.51)
Anxiety	635 (1.729)/1461 (0.8046)	2.11 (1.91-2.33)	164 (1.24)/534 (0.8183)	1.50 (1.25-1.80)	474 (2.011)/930 (0.7972)	2.48 (2.20-2.79)
Stress-related disorder	340 (0.9198)/663 (0.3651)	2.33 (2.03-2.68)	88 (0.6624)/231 (0.354)	1.75 (1.35-2.27)	255 (1.074)/432 (0.3703)	2.71 (2.29-3.19)
Substance misuse	719 (1.961)/1915 (1.055)	1.83 (1.65-2.04)	189 (1.431)/691 (1.059)	1.23 (1.01-1.50)	533 (2.266)/1232 (1.056)	2.25 (1.97-2.56)
Psychotic disorder	45 (0.1208)/139 (0.07655)	1.57 (1.06-2.34)	18 (0.1348)/55 (0.08428)	1.66 (0.83-3.33)	27 (0.1126)/85 (0.07287)	1.37 (0.81-2.33)

^aPer 1000 person years. ^bBased on the matched cohort study, HR (95% CI) was derived from the Cox regression models, stratified by matching identifier (birth year, sex), and adjusted for ethnicity, educational attainment, smoking status, drinking status, annual household income, Townsend’s deprivation index (as a continuous variable), body mass index, physical activity, history of other psychiatry disorders, and Charlson’s comorbidity index. Abbreviation: HR: hazard ratios; CI: confidence interval; OA: osteoarthritis.