Genetic Determinants of the Association between Osteoarthritis and Psychiatric Disorders
Table 2
The genetic association between psychiatric disorders and osteoarthritis (OA) assessed by polygenic risk score (PRS) analysis.
Specific psychiatric disorders
Hip/knee OA
Hip OA
Knee OA
Psychiatric disorders PRS→OA
OA PRS→psychiatric disorders
Psychiatric disorders PRS→OA
OA PRS→psychiatric disorders
Psychiatric disorders PRS→OA
OA PRS→psychiatric disorders
OR (95% CI)a
OR (95% CI)a
OR (95% CI)a
OR (95% CI)a
OR (95% CI)a
OR (95% CI)a
Depression
1.03 (1.01-1.04)
3.3110-06
1.03 (1.02-1.05)
1.2210-04
1.00 (0.99-1.02)
0.642
1.01 (1.00-1.03)
0.068
1.04 (1.03-1.05)
8.5210-09
1.04 (1.02-1.05)
1.9710-05
Anxiety
1.01 (1.00-1.02)
0.0458
1.07 (1.05-1.09)
5.6510-14
1.01 (0.99-1.02)
0.448
1.03 (1.01-1.05)
2.3910-04
1.01 (1.00-1.02)
0.173
1.06 (1.04-1.08)
4.4310-12
Stress-related disorder
1.03 (1.02-1.05)
5.9510-10
1.03 (1.01-1.06)
0.0111
1.01 (1.00-1.03)
0.161
1.01 (0.98-1.03)
0.593
1.04 (1.03-1.06)
2.2610-11
1.04 (1.01-1.06)
2.2310-03
Substance misuse
1.00 (0.99-1.01)
0.853
1.07 (1.05-1.09)
1.2410-14
0.99 (0.98-1.01)
0.439
1.02 (1.00-1.04)
0.013
1.01 (0.99-1.02)
0.348
1.08 (1.06-1.09)
2.2310-15
aORs and 95% CIs (per standard deviation increase in the corresponding PRS) were estimated by logistic regression models adjusting for age, sex, genotyping array, and the first ten ancestry principal components. Abbreviation: OA: osteoarthritis; OR: odds ratio; CI: confidence interval; PRS: polygenic risk score.
