Genetic Determinants of the Association between Osteoarthritis and Psychiatric Disorders

Table 3

Genetic association between depression and osteoarthritis (OA) assessed by LD score regression.

	Hip/knee OA		Hip OA		Knee OA
	rg (95% CI)^a		rg (95% CI)^a		rg (95% CI)^a
Depression	0.17 (0.12~0.22)	1.3310^-11	0.06 (0.00~0.12)	0.0488	0.20 (0.15~0.25)	1.7510^-15
Anxiety	0.07 (0.10~0.25)	0.4178	0.06 (-0.14~0.25)	0.5638	0.06 (-0.12~0.24)	0.5196
Stress-related disorder	0.28 (0.17~0.39)	3.7610^-07	0.15 (0.02~0.29)	0.0295	0.29 (0.19~0.40)	9.1210^-08
Substance misuse	-0.02 (-0.14~0.10)	0.7629	0.02 (-0.10~0.14)	0.7470	-0.07 (-0.20~0.07)	0.3220

^aGenetic association was assessed by LD score regression. rg: for genetic; CI: confidence interval.