Edaravone Improved Behavioral Abnormalities, Alleviated Oxidative Stress Inflammation, and Metabolic Homeostasis Pathways in Depression

Table 2

Grading of histopathological changes in the brain in the control and experimental rats. Scoring was done as follows: NO (0); Mild (1); Moderate (2); and Severe (3). Microglial nodule (blue arrows), basophilic necrotic neuron (yellow arrows), and vacuolization (red arrows) were observed.

Groups	Microglial nodule	Basophilic necrotic neuron	Vacuolization
Control	0	0	0
PWSI	2	2	2
EDV (6 mg/kg)	0	0	0
PWSI+EDV (1.5 mg/kg)	0	1	0
PWSI+EDV (3 mg/kg)	0	1	0
PWSI+EDV (6 mg/kg)	0	0	0