Advances in Zebrafish as a Comprehensive Model of Mental Disorders

Figure 2

Summary of current BBB models. (a) Similar to mammals, the site of the zebrafish BBB is in endothelial cells, which are connected by the tight junction and are in close contact with pericytes. Zebrafish radial glia process resembles mammalian astrocytes. (b) As in zebrafish, the human BBB site is capillary endothelial cells connected by special tight junctions. Human neurovascular unit also includes pericytes and astrocyte end feet, which are more prevalent in the human brain than in the mouse brain. (c) Mice BBB is also the site in endothelial cells connected by special tight junctions. (d) Hemolymph–brain barrier separates the neuropil from the hemolymph in the fruit fly, hemolymph–brain barrier site in subperineurial glial cells.(e, f) Like humans, rabbit and pig have almost the same BBB structure.

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