Advances in Zebrafish as a Comprehensive Model of Mental Disorders

Figure 8

Mechanisms of schizophrenia-regulation of glutamate synapse. Glutamatergic neurotransmission plays an important role in schizophrenia. Schizophrenic-related genes in the glutamatergic neurotransmission pathway include GRIN2A, GRIA1, SRR, CACNA1C, genes encoding the ARC complex, and other several genes encoding schizophrenic-related proteins. The NMDA-type glutamate receptor is modulated by D-serine, a coagonist synthesized by SRR. VCDDs are some proteins encoded by CACNA1C, and they are involved in the regulation of intersynaptic signaling through intracellular calcium channels. In response to glutamate receptor activation, proteins associated with postsynaptic scaffold aging (including PSD95, CACNG2, several kinases, RHO, CDC42, RAC family of small G proteins, and ARC complex) are mainly involved in intracellular signal transduction. Here, the square dotted lines are related proteins that determine the basis of synaptic plasticity. Reproduced with permission from [295].