Advances in Zebrafish as a Comprehensive Model of Mental Disorders

Table 2

Summary of zebrafish mode in CNS diseases.

CNS diseases	Methods	Details	Biomarkers	Ref.
PTSD	Gene editing	PAC1	-	[102–104]
		TPH1
		TPH2
AD	Gene editing	APPsw	DA	[80, 114, 116, 117, 120, 121, 123–141]
		A152T-Tau
		PEN1	NA
		PSEN2
		AppA
		AppB	Dihydroxy-phenylacetic acid
		Bace1
	Drug-induction	OKA
		Benzo[a]pyrene
	Metal ion-induction	Al
		Cu
		Co
		Fe^3+
		Zn^2+
		Ag^2+
		Pb^2+
		Ni^2+
		Hg^2+
		Mn^2+
		Cd^2+
		Cr4O^2-
PD	Gene editing	LRRK2	α-syn	[87, 156, 157, 163, 166, 168–172]
		GBA
		Parkin
		DJ1
		Pink1
		ATP13A2
	Drug-induction	MPTP
		6-OHDA	DA
		Rotenone
		Paraquat
		Ziram
		Benomyl
		DEPe
Epilepsy	Gene editing	scn1a	GABA	[190, 191, 193, 198, 200, 204, 205, 207–211]
		KCNJ10
		KCNQ3
			GFAP
		got2a
		ubtor
		stx1b
		stxbp1	CHD2
		cacna1a
		CHD2
	Drug-induction	PTZ
		AG
		KA