Research Article
Exploring the Interplay between Mitochondrial DNA and Lifestyle Factors in the Pathogenesis of Psychiatric Disorders
Table 2
Mitochondrial gene-by-environment interaction mutations with main effects.
| Phenotype | Group | Mutation | Gene | SNV-environment interactions | SNV effects | Environment | Beta | SE | | Beta | SE | |
| Anx_self | Total | T9716C | MT-CO3 | Alcohol | -0.0051 | 0.0015 | 0.0005 | 0.0279 | 0.0119 | 0.0191 | Female | T9716C | MT-CO3 | Alcohol | -0.0089 | 0.0028 | 0.0013 | 0.0425 | 0.0173 | 0.0143 | Male | T5999C | MT-CO1 | Smoke | -0.0029 | 0.0014 | 0.0340 | -0.0319 | 0.0139 | 0.0218 | Male | C14620T | MT-ND6 | Smoke | -0.0027 | 0.0014 | 0.0477 | -0.0311 | 0.0138 | 0.0241 | Male | A263G | MT-DLOOP | Smoke | 0.0049 | 0.0020 | 0.0145 | 0.0415 | 0.0200 | 0.0380 |
| Anx_score | Total | A9667G | MT-CO3 | Alcohol | -0.0380 | 0.0126 | 0.0025 | 0.2059 | 0.1044 | 0.0487 | Female | G4580A | MT-ND2 | Alcohol | 0.0337 | 0.0146 | 0.0209 | 0.2062 | 0.0936 | 0.0275 |
| Dep_score | Male | T5004C | MT-ND2 | Alcohol | -0.0257 | 0.0131 | 0.0492 | 0.3084 | 0.1237 | 0.0127 | Male | A14582G | MT-ND6 | Alcohol | -0.0278 | 0.0138 | 0.0432 | 0.2743 | 0.1304 | 0.0354 | Male | C3992T | MT-ND1 | Alcohol | -0.0343 | 0.0122 | 0.0052 | 0.2362 | 0.1162 | 0.0421 | Male | C3992T | MT-ND1 | Smoke | 0.0236 | 0.0108 | 0.0294 | 0.2362 | 0.1162 | 0.0421 | Male | A4024G | MT-ND1 | Alcohol | -0.0300 | 0.0133 | 0.0246 | 0.2537 | 0.1273 | 0.0464 |
| Self-harm | Total | G13759A | MT-ND5 | Alcohol | 0.0019 | 0.0009 | 0.0408 | 0.0221 | 0.0082 | 0.0069 | Total | T8448C | MT-ATP8 | Alcohol | 0.0030 | 0.0011 | 0.0069 | 0.0216 | 0.0094 | 0.0218 |
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Note: SE: standard error; SNV: single nucleotide variation; Anx_self: self-reported anxiety; Anx_score: anxiety score; Dep_score: depression score.
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