Exploring the Interplay between Mitochondrial DNA and Lifestyle Factors in the Pathogenesis of Psychiatric Disorders

Table 2

Mitochondrial gene-by-environment interaction mutations with main effects.

Phenotype	Group	Mutation	Gene	SNV-environment interactions				SNV effects
				Environment	Beta	SE		Beta	SE
Anx_self	Total	T9716C	MT-CO3	Alcohol	-0.0051	0.0015	0.0005	0.0279	0.0119	0.0191
	Female	T9716C	MT-CO3	Alcohol	-0.0089	0.0028	0.0013	0.0425	0.0173	0.0143
	Male	T5999C	MT-CO1	Smoke	-0.0029	0.0014	0.0340	-0.0319	0.0139	0.0218
	Male	C14620T	MT-ND6	Smoke	-0.0027	0.0014	0.0477	-0.0311	0.0138	0.0241
	Male	A263G	MT-DLOOP	Smoke	0.0049	0.0020	0.0145	0.0415	0.0200	0.0380
Anx_score	Total	A9667G	MT-CO3	Alcohol	-0.0380	0.0126	0.0025	0.2059	0.1044	0.0487
	Female	G4580A	MT-ND2	Alcohol	0.0337	0.0146	0.0209	0.2062	0.0936	0.0275
Dep_score	Male	T5004C	MT-ND2	Alcohol	-0.0257	0.0131	0.0492	0.3084	0.1237	0.0127
	Male	A14582G	MT-ND6	Alcohol	-0.0278	0.0138	0.0432	0.2743	0.1304	0.0354
	Male	C3992T	MT-ND1	Alcohol	-0.0343	0.0122	0.0052	0.2362	0.1162	0.0421
	Male	C3992T	MT-ND1	Smoke	0.0236	0.0108	0.0294	0.2362	0.1162	0.0421
	Male	A4024G	MT-ND1	Alcohol	-0.0300	0.0133	0.0246	0.2537	0.1273	0.0464
Self-harm	Total	G13759A	MT-ND5	Alcohol	0.0019	0.0009	0.0408	0.0221	0.0082	0.0069
	Total	T8448C	MT-ATP8	Alcohol	0.0030	0.0011	0.0069	0.0216	0.0094	0.0218

Note: SE: standard error; SNV: single nucleotide variation; Anx_self: self-reported anxiety; Anx_score: anxiety score; Dep_score: depression score.