Exploring the Interplay between Mitochondrial DNA and Lifestyle Factors in the Pathogenesis of Psychiatric Disorders

Table 3

Associations of gene-by-environment interactions with risk and severities of anxiety or depression.

Type	Group	Mutation	Gene	Environment	Self-report			Score
					Beta	SE		Beta	SE
Anxiety	Female	A15924G	MT-TT	Smoke	-0.0032	0.0013	0.0116	-0.0257	0.0097	0.0081
	Female	G11914A	MT-ND4	Alcohol	0.0052	0.0022	0.0199	0.0415	0.0189	0.0282
	Male	A9667G	MT-CO3	Alcohol	0.0041	0.0017	0.0169	-0.0528	0.0144	0.0002
	Male	T10463C	MT-TR	Alcohol	0.0015	0.0006	0.0233	0.0157	0.0052	0.0024
	Male	A4917G	MT-ND2	Alcohol	0.0015	0.0007	0.0301	0.0155	0.0054	0.0040
	Male	G15928A	MT-TT	Alcohol	0.0013	0.0007	0.0430	0.0151	0.0053	0.0042
	Male	G14905A	MT-CYB	Alcohol	0.0014	0.0007	0.0378	0.0151	0.0053	0.0047
	Male	G8697A	MT-ATP6	Alcohol	0.0014	0.0007	0.0393	0.0151	0.0054	0.0048
	Male	A11812G	MT-ND4	Alcohol	0.0016	0.0007	0.0300	0.0168	0.0060	0.0049
	Male	A750G	MT-RNR1	Smoke	0.0042	0.0015	0.0054	0.0299	0.0125	0.0166
Depression	Total	C3992T	MT-ND1	Alcohol	-0.0028	0.0011	0.0075	-0.0229	0.0101	0.0232
	Male	T6221C	MT-CO1	Alcohol	0.0034	0.0015	0.0259	0.0287	0.0138	0.0376
	Male	C3992T	MT-ND1	Alcohol	-0.0030	0.0013	0.0275	-0.0343	0.0122	0.0052
	Male	T10463C	MT-TR	Alcohol	0.0014	0.0006	0.0339	0.0148	0.0058	0.0105

Note: SE: standard error.