Exploring the Interplay between Mitochondrial DNA and Lifestyle Factors in the Pathogenesis of Psychiatric Disorders

Table 4

Mitochondrial SNVs interacting with various environmental variables in psychiatric disorders.

Type	Group	Mutation	Gene	Phenotype	Alcohol			Smoke
					Beta	SE		Beta	SE
Anxiety	Total	C150T	MT-DLOOP	Anx_self	-0.0013	0.0006	0.0334	0.0011	0.0006	0.0477
	Female	A15924G	MT-TT	Anx_score	0.0397	0.0108	0.0002	-0.0257	0.0097	0.0081
	Female	G11914A	MT-ND4	Anx_score	0.0415	0.0189	0.0282	-0.0469	0.0179	0.0086
	Female	C3992T	MT-ND1	Anx_self	-0.0051	0.0024	0.0328	0.0043	0.0020	0.0293
Depression	Total	C3992T	MT-ND1	Dep_score	-0.0229	0.0101	0.0232	0.0241	0.0090	0.0073
	Male	T6221C	MT-CO1	Dep_self	0.0034	0.0015	0.0259	-0.0057	0.0019	0.0025
	Male	C6371T	MT-CO1	Dep_self	0.0040	0.0016	0.0109	-0.0060	0.0020	0.0026
	Male	C3992T	MT-ND1	Dep_score	-0.0030	0.0013	0.0275	0.0236	0.0108	0.0294
Self-harm	Female	G11914A	MT-ND4	Self-harm	0.0043	0.0015	0.0049	-0.0054	0.0016	0.0005

Note: SE: standard error; Anx_self: self-reported anxiety; Anx_score: anxiety score; Dep_self: self-reported depression; Dep_score: depression score. denotes interaction with Mutation.