Exploring the Interplay between Mitochondrial DNA and Lifestyle Factors in the Pathogenesis of Psychiatric Disorders

Table 5

Cooccurring gene-by-environment interactions across psychiatric disorders.

Mutation	Gene	Environment	Anxiety			Depression			Self-harm
			Phenotype	Beta		Phenotype	Beta		Phenotype	Beta
T5004C	MT-ND2	Alcohol	Anx_self	-0.0026	0.0407	Dep_self	-0.0024	0.0319	Self_harm	-0.0018	0.0379
G9123A	MT-ATP6	Alcohol	Anx_self	-0.0030	0.0208	Dep_self	-0.0024	0.0332	Self_harm	-0.0017	0.0435
A15924G	MT-TT	Alcohol	Anx_score	0.0152	0.0087	Dep_score	0.0124	0.0438	—	—	—
		Smoke	—	—	—	—	—	—	Self_harm	-0.0010	0.0498
G1719A	MT-RNR2	Alcohol	Anx_score	0.0187	0.0001	Dep_score	0.0175	0.0005	—	—	—
C1721T	MT-RNR2	Alcohol	Anx_score	0.0253	0.0009	Dep_score	0.0225	0.0052	—	—	—
A9667G	MT-CO3	Alcohol	Anx_score	-0.0380	0.0025	Dep_score	-0.0264	0.0449	—	—	—
G16391A	MT-DLOOP	Alcohol	Anx_score	0.0213	0.0050	Dep_score	0.0184	0.0213	—	—	—
A4529T	MT-ND2	Alcohol	Anx_score	0.0207	0.0071	Dep_score	0.0218	0.0073	—	—	—
A13780G	MT-ND5	Alcohol	Anx_score	0.0194	0.0103	Dep_score	0.0197	0.0133	—	—	—
T10915C	MT-ND4	Alcohol	Anx_score	0.0322	0.0112	Dep_score	0.0284	0.0324	—	—	—
G12501A	MT-ND5	Alcohol	Anx_score	0.0165	0.0238	Dep_score	0.0212	0.0057	—	—	—
T10238C	MT-ND3	Alcohol	Anx_score	0.0164	0.0263	Dep_score	0.0191	0.0142	—	—	—
A7768G	MT-CO2	Alcohol	Anx_score	0.0140	0.0285	Dep_score	0.0140	0.0377	—	—	—
C3992T	MT-ND1	Alcohol	Anx_self	-0.0029	0.0158	Dep_self	-0.0028	0.0075	—	—	—
			—	—	—	Dep_score	-0.0229	0.0232	—	—	—
		Smoke	—	—	—	Dep_score	0.0241	0.0073	—	—	—

Note: Anx_self: self-reported anxiety; Anx_score: anxiety score; Dep_self: self-reported depression; Dep_score: depression score.