Research Article
Predictive Models for Suicide Attempts in Major Depressive Disorder and the Contribution of EPHX2: A Pilot Integrative Machine Learning Study
Table 1
Summary of the baseline clinical characteristics comparing HV versus MDD and DNS versus DSA.
| | HV () | MDD () | p value | MDD | p value | | DNS () | DSA () |
| | Age (years) | 26 (22-33) | 25 (21-29) | 0.028 | 25 (22-31) | 23 (20-26) | 0.025 | | Gender | | | | | | | | Male | 52 (47%) | 110 (30%) | 0.001 | 76 (33%) | 34 (26%) | 0.128 | | Female | 58 (53%) | 252 (70%) | 153 (67%) | 99 (74%) | | Marriage status | | | | | | | | Single | 64 (58%) | 243 (67%) | 0.016 | 153 (67%) | 90 (68%) | 0.963 | | Married | 46 (42%) | 107 (30%) | 69 (30%) | 38 (29%) | | divorced or widowed | 0(0%) | 11(3%) | 7(3%) | 4(3%) | | Education | | | | | | | | ≤12 years | 33 (30%) | 137 (38%) | 0.133 | 62 (27%) | 75 (56%) | <0.001 | | >12 years | 77 (70%) | 225 (62%) | 167 (73%) | 58 (44%) | | Family history of psychiatric disorder | | | | | | | | No | 110 (100%) | 245 (68%) | <0.001 | 175 (76%) | 70 (53%) | 0.857 | | Yes | 0 (0%) | 62 (17%) | 45 (20%) | 17 (13%) | | Family history of major depression disorder | | | | | | | | No | 110 (100%) | 282 (78%) | 0.002 | 199 (87%) | 83 (62%) | 0.153 | | Yes | 0 (0%) | 25 (7%) | 21 (9%) | 4 (3%) | | Family history of suicide | | | | | | | | No | 110 (100%) | 302 (83%) | 0.178 | 217 (95%) | 85 (64%) | 0.56 | | Yes | 0 (0%) | 5 (1%) | 3 (1%) | 2 (2%) | | History of psychiatric medicine use | | | | | | | | No | 110 (100%) | 254 (70%) | <0.001 | 187 (82%) | 67 (50%) | 0.095 | | Yes | 0 (0%) | 53 (15%) | 33 (14%) | 20 (15%) | | BMI | 21.50 (19.71-24.10) | 20.06 (18.43-22.55) | <0.001 | 20.28 (18.42-22.79) | 19.77 (18.53-22.43) | 0.466 | | Age at onset (years) | / | / | / | 23 (19-28) | 19 (16-22) | <0.001 | | Duration of current episode (weeks) | / | / | / | 12 (4-48) | 24 (5.75-116.50) | 0.006 | | Recurrent major depressive episode | | | | | | | | No | / | / | / | 121 (53%) | 42 (32%) | 0.27 | | Yes | / | / | / | 98 (43%) | 45 (34%) | | HAMD-total score | / | / | / | 29.50 (25.75-35) | 34 (29-37) | <0.001 |
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HV: healthy volunteers; MDD: major depressive disorder; DNS: depressed non-suicide attempters; DSA: depressed suicide attempters; HAMD: Hamilton MDD Scale-24.
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