Risk Factors, Prognosis, Influence on the Offspring, and Genetic Architecture of Perinatal Depression Classified Based on the Depressive Symptom Trajectory

Figure 3

PRS analysis. (a) The prevalence of each PD subtype was compared among PRS (left: MDD; right: PMS) quintiles using multiple logistic regression, considering quintile 1 (lowest genetic load) as a reference, adjusted for age and five principal components. The -axis is the PRS quintiles, and the -axis is the odds ratio. The asterisk indicates statistical significance (). (b) K6 scores obtained twice during pregnancy and EPDS scores obtained at 1 and 6 months postpartum were plotted by PRS (left: MDD; right: PMS) quintiles. The -axis represents the time of the questionnaires, and the -axis represents the mean difference between questionnaire scores in each quintile group and the healthy control. (c) The heat map indicates the P for trend calculated using PRS with different value thresholds (0.5, 0.1, 0.05, 0.01, and 0.005). The -axis indicates PRS phenotype and value thresholds, and the -axis represents PD subtypes.

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