Research Article
Meta-Analysis of Brain Volumetric Abnormalities in Patients with Remitted Major Depressive Disorder
Table 1
Sample characteristics and MRI procedures of included cross-sectional studies.
| | Study (publication year) | Number (female) | Mean age (y) | Age of onset | Illness duration (months) | No. of episodes | Mean depression severity | Therapy | Comorbidity with anxiety (rate%) | MRI procedures | | MDD | HC | MDD | HCs | Field strength | Voxel size (mm3) | MRI scanner |
| | Arnone et al. (2013) [23] | 25 (20) | 66 (46) | 34.5 | 32.1 | 22.0 | NA | 2.8 | 2.2 (MADRS) | Medication-free | 0/23 (0%) | 1.5 T | | Philips Intera | | Fang et al. (2015) [24] | 20 (8) | 18 (8) | 59.2 | 59.1 | 56.1 | 43.2 | 2.1 | 6.4 (HDRS-17) | Antidepressants | NA | 1.5 T | | Siemens | | Klauser et al. (2015) [22] | 27 (18) | 33 (21) | 35.0 | 34.7 | 10.29 | 137.4 | 3.1 | 13.0 (BDI) | Antidepressants | 22/56 (39%) | 1.5 T | | Siemens | | Kong et al. (2014) [25] | 24 (14) | 28 (14) | 36.1 | 32.1 | NA | 4.12 | NA | 3.4 (HDRS) | Fluoxetine | NA | 1.5 T | | GE Signa | | Lemke et al. (2022) [26] | 42 (24) | 63 (39) | 38.79 | 36.48 | NA | 14.06 | NA | 2.55 (HDRS) | Antidepressants | NA | 3.0 T | NA | NA | | Li et al. (2010) [27] | 19 (13) | 25 (19) | 42.6 | 40.6 | 36.5 | 112.8 | 3.5 | 3.4 (HDRS) | SSRI/SNRI/bupropion | 13/44 (30%) | 1.5 T | | NA | | Liu et al. (2014) [17] | 19 (19) | 19 (19) | 37.6 | 36.8 | NA | 88.44 | 2.39 | 4.6 (HDRS) | Antidepressants | NA | 1.5 T | | Siemens Trio | | Salvadore et al. (2011) [28] | 27 (21) | 107 (60) | 40.2 | 36.2 | NA | 181.2 | NA | 1.6 (MADRS) | Medication-free | NA | 3.0 T | | Milwaukee | | Serra-Blasco et al. (2013) [29] | 22 (20) | 32 (23) | 48 | 46.0 | 43.5 | 214.3 | 4.56 | 4.0 (HDRS) | Antidepressants | NA | 3.0 T | NA | Philips Achieva | | Takamiya et al. (2021) [18] | 27 (13) | 21 (19) | 67.5 | 63.0 | NA | 60 | NA | 6.0 (HDRS-17) | MECT+antidepressant+antipsychotics+benzodiazepine | NA | 3.0 T | | GE Signa HDxt | | Wang et al. (2017) [30] | 23 (12) | 25 (13) | 38.74 | 39.52 | 33.90 | 70.35 | NA | 3.83 (HDRS-17) | MECT+antidepressant+antipsychotics | NA | 3.0 T | | GE Signa HDxt |
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BDI = Beck Depression Inventory; HCs = healthy controls; HDRS-17 = 17-item Hamilton Depression Rating Scale; m = months; MADRS = Montgomery and Åsberg Depression Rating Scale; MAOI = monoamine oxidase inhibitors; MDD = major depressive disorder; MRI = magnetic resonance imaging; NaSSA = noradrenergic/specific serotonergic agents; NDRI = norepinephrine dopamine reuptake inhibitor; pre-tx = pretreatment; post-tx = posttreatment; SSRI = specific serotonin reuptake inhibitors; SNRI = serotonin norepinephrine reuptake inhibitors; TCA = tricyclic antidepressants; w = weeks; y = years. Antidepressants include SSRI, SNRI TCA, NDRI, NaSSA, and MAOI.
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