Pharmacological and Psychological Treatment Have Common and Specific Effects on Brain Activity in Obsessive-Compulsive Disorder

Table 2

Significant results from the interaction analyses to investigate common () and specific () treatment effects.

Contrast	MNI coordinates			Cluster size or value	value	Region (AAL atlas)	BA	Direction of effect
	Face matching task
OCD vs. HC	—	—	—	—	—	—	—	—
SSRI vs. CBT	-2	-52	-6	520	0.001^a	Cerebellum	18, 19	↑ CBT
	-42	-18	8	249	0.026^a	Posterior insula—Heschl’s gyrus L	48	↓ SSRI, ↑ CBT
Stop signal task
OCD vs. HC	—	—	—	—	—	—	—	—
SSRI vs. CBT	-24	-14	30	362	0.006^a	Insula—caudate nucleus L	48	↑ CBT
	18	-86	-6	235	0.034^a	Lingual gyrus R	18, 19	↓ SSRI, ↑ CBT
	-36	38	-2	4.70	0.002^b	Orbitofrontal cortex L	47	↓ SSRI, ↑ CBT
	-26	10	60	4.06	0.013^b	Middle frontal gyrus L	8	↓ SSRI, ↑ CBT
Symptom provocation
OCD vs. HC	44	4	-10	4.46	0.003^b	Insula R	48	↓ in patients
SSRI vs. CBT	32	-58	8	268	0.030^a	Calcarine sulcus—hippocampus R	19, 37	↑ SSRI, ↓ CBT

^aWhole-brain cluster-level correction. ^bSVC peak-level correction. Significant post hoc paired -test between pre- and posttreatment weighted contrasts. Groups: OCD: obsessive-compulsive disorder; SSRI: selective serotonin reuptake inhibitors; CBT: cognitive behavioral therapy; HC: healthy controls. Direction of effect: ↑ increased activity, ↓ decreased activity.