Association of TAP Gene Polymorphisms and Risk of Cervical Intraepithelial Neoplasia

Table 5

Association between TAP gene haplotype combinations and risk of cervical intraepithelial neoplasia (CIN).

Haplotypes	Haplotype frequency		𝑃	OR (95% CI)
	Controls in %	CIN in %
(t1135-t1341-t1693-t1993-t2254)
wt-wt-wt-wt-wt (reference)	31.2%	28.8%	—	1.0
mut-wt-wt-wt-wt	9.7%	7.3%	0.006	0.5 (0.4–0.8)
wt-mut-wt-wt-mut	5.5%	6.5%	0.7	1.1 (0.6–1.9)
wt-wt-wt-mut-wt	20.9%	16.4%	0.2	0.8 (0.6–1.1)
Others^a	32.7%	43.6%	0.1	2.0 (0.8–4.7)

aHaplotypes <5% were pooled (= others).
TAP: transporter associated with antigen processing.
CIN: cervical intraepithelial neoplasia.
OR (95% CI): odds ratio (95% confidence interval).