Impact of IL12B Gene rs 3212227 Polymorphism on Fibrosis, Liver Inflammation, and Response to Treatment in Genotype 4 Egyptian Hepatitis C Patients

Table 7

Influence of IL12B 1188 A/C SNP stratified according to gender parameter on response to antiviral therapy.

Genotype^a	SVR (𝑁=74)	NR (𝑁=59)	P value
AA^b genotype			0.977
M	29 (39.2%)	17 (28.8%)
F	8 (10.8%)	14 (23.7%)
AC^c genotype
M	22 (29.7%)	14 (23.7%)
F	6 (8.1%)	10 (17%)
CC^d genotype
M	7 (9.5%)	2 (3.4%)
F	2 (2.7%)	2 (3.4%)
A allele
M	80 (54.1%)	48 (40.7%)	0.822
F	22 (14.9%)	38 (32.2%)
C allele
M	36 (24.3%)	18 (15.2%)
F	10 (6.7%)	14 (11.9%)

M: male; F: female; across tab for distribution of males and females in relation to IL12B genotypes 𝑃=0.981; bcross tab for distribution of AA males and females in relation to response 𝑃=0.039; ccross tab for distribution of AC males and females in relation to response 𝑃=0.115; dcross tab for distribution of CC males and females in relation to response 𝑃=0.317.