Research Article

Proteomic Analysis of Serum and Urine of HIV-Monoinfected and HIV/HCV-Coinfected Patients Undergoing Long Term Treatment with Nevirapine

Table 1

List of proteins detected as differentially regulated in urine of patients undergoing long term NVP treatment and normal controls.

Protein name Database ID numberProtein ID scoreFunctionLocalizationMass (Da)Peptide sequence

ADAMTS12gi∣1242971233.21Protein metabolismUnknown1036.6585KCNQQACK
Sacsingi∣3272005852.49Immune responseMembrane911.5248FTSEVAXR
NADPH oxidasegi∣348109912.66Immune responseCytoplasm722.5438YTVVXK
Ubiquitin-conjugating enzyme E2gi∣2699143742.24Ubiquitin metabolismCytoplasm849.2900AGSMALKR
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3gi∣228978612.59TranscriptionNucleus672.2483LPGAGEK
dyneingi∣1196277414.40SingleCytoplasm733.7764LFAQVR
Dystroglycangi∣2949972829.68CytoskeletonCytoplasm679.6234KPPLPK
E3 ubiquitin-protein ligase HECTD1gi∣11849833722.38Ubiquitin metabolismCytoplasm870.7503KASLALIR
FL100154gi∣186765146.78OthersUnknown1532.2699PEMTGVTVSGLTPAR
hCG1783738gi∣1196064811.35OthersUnknown756.2752KPALGNR
hCG2042782gi∣1195742835.61OthersUnknown972.8246VAMTVIKPV
hCG2045758gi∣1196262125.75OthersUnknown867.1841RVASAYLS
Protein HEG homolog 1gi∣338714868.09Cell developmentMembrane850.1389LFDLADR
hydroxyacylglutathione hydrolasegi∣1196060163.62Carbohydrate metabolismMitochondria782.3398VYGGDDR
Hypothetical proteingi∣602192247.34OthersUnknown1568.0209DMQMGPGLFLRMR
IgA nephropathy-related protein 1gi∣3071335165.16SingleMembrane795.7409GPVSPPNK
Immunoglobulin heavy chain VHDJ regiongi∣216698231.48Immune responseCytoplasm773.9408RGGVGTTK
Immunoglobulin kappa light chaingi∣628609603.36Immune responseCytoplasm920.3153TVAAPSVFK
Keratingi∣3256778617.72Cell developmentCytoplasm701.4250MDLHGK
KIAA0591gi∣294211784.69ApoptosisMitochondria833.9171SYTMMGK
KIAA0895gi∣42402795.22OthersUnknown835.4904DIGRFVK
Patched domain containing proteingi∣3262053573.36TransportMembrane674.6955LSKNGR
KIAA1409gi∣11960193726.30Response to stressMembrane856.7432IAVSAIQR
KIAA2010gi∣248991841.10Protein metabolismCytoplasm902.6365EDTLPLSK
Metabotropic glutamate receptor 5 gi∣45041437.70SingleNucleus1406.2405YEIMNFKEMGK
MHC class 1 antigengi∣1232782157.54Immune responseMembrane688.0275QAPTDR
Myosin light chain kinase 2gi∣140435383.01TransportCytoplasm1434.2871DFVSNLIVKDQR
Peroxisome proliferator-activated receptor alphagi∣15145951.01TranscriptionNucleus758.7757FDFAMK
Progesterone-induced-blocking factor 1gi∣39256856.64TranscriptionCytoplasm986.7480QNSLIXKR
Pleckstrin homology domain containing family A member 6gi∣375955482.93Lipid metabolismCytoplasm757.5746SVPQAVR
Poly(ADP-ribose) polymerase 1gi∣1195901917.36TranscriptionNucleus1475.5247LQGHVPQTSLQLR
Suppressor of cytokine signaling 5gi∣232739343.30SingleCytoplasm783.9406RDSYSR
REST corepressorgi∣3449258455.18TranscriptionNucleus673.1253GPEVSGK
REST corepressor 3gi∣215950827.97TranscriptionNucleus714.2440GPELLGK
Uncharacterized protein FLJ37004gi∣747297103.79OthersUnknown1519.9062ATAAAARGSEVSGEGGK
Serine/threonine protein kinase RIO3gi∣1196215582.00TransportMembrane1263.2434ENVGDGIGMDLK
Serine/threonine protein kinase PLK4gi∣21258142.52SingleCytoplasm866.4060DRASFNR
SEC14-like 4gi∣1195803007.04TransportMembrane819.6610SSATLWR
SH2 domain containing protein 3Cgi∣47047393.24SingleMembrane658.6454TAVGRR
Sorting nexin-3gi∣31269792.35TransportMembrane1017.4337AETVADTRR
NEDD8-activating enzyme E1 catalytic subunitgi∣33425641.45TranscriptionNucleus744.0996LTQGVVK
Uncharacterized protein gi∣2546929132.93OthersUnknown1000.3987RLLNELDK
Ribosomal RNA upstream binding transcription factorgi∣19166152.03TranscriptionNucleus780.6412LRGPNPK
Vacuolar protein sorting-associated protein 45gi∣181050635.13TranscriptionNucleus838.4481KMSGTVSK
WD repeat-containing protein 46gi∣2567731767.41TranscriptionNucleus696.2765KPQVPK
Coiled-coil domain containing protein 105gi∣2264928922.14TranscriptionNucleus540.5465APTPR
17-beta-Hydroxysteroid dehydrogenase 14gi∣598895787.76Cell divisionCytoplasm506.0660ATGTR