Mig-6 Gene Knockout Induces Neointimal Hyperplasia in the Vascular Smooth Muscle Cell

Figure 5

Migration and proliferation of MIG-6-silenced human vascular SMCs. (a) Changes of cell migration in response to EGFR activators. (b) Changes of cell migration in response to EGFR inhibitors. (c) Changes of cell proliferation in response to EGFR activators. (d) Changes of cell proliferation in response to EGFR inhibitors. EGF 10 ng/mL, AngII 100 mM, AG1478I 250 nM, and ARB 100 M. EGF, epidermal growth factor; AngII, angiotensin II; ARB, angiotensin receptor blocker. , , and versus Mig-6 ^f/f; and versus Mig-6 ^f/f control; , , and versus Mig-6 ^d/d control.

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