Research Article

Gene Expression Profiling of Colorectal Tumors and Normal Mucosa by Microarrays Meta-Analysis Using Prediction Analysis of Microarray, Artificial Neural Network, Classification, and Regression Trees

Table 2

55 differential expressed genes in colorectal tumors of the primary screening.

Accession numberGene symbolGene nameChromosomeFold change*

HGNC: 74 ABCG2 ATP-binding cassette, subfamily G (white), member 24q22−6.26
HGNC: 22204 AHCYL2 Adenosylhomocysteinase-like 27q32.1−5.82
HGNC: 642AQP8 Aquaporin 816p12−6.56
HGNC: 17107 BEST2 Bestrophin 219p13.2−4.52
HGNC: 1143 BTNL3 Butyrophilin-like 35q35.3−6.03
HGNC: 21214 C6orf105 Chromosome 6 open reading frame 1056p24.1−7.31
HGNC: 28180 C9orf125 Chromosome 6 open reading frame 1059q31.1−4.23
HGNC: 1368 CA1 Carbonic anhydrase I8q21.2−6.22
HGNC: 1375 CA4 Carbonic anhydrase IV17q23−3.95
HGNC: 1381 CA7 Carbonic anhydrase VII16q22.1−5.39
HGNC: 30072 CD177 CD177 molecule19q13.2−4.65
HGNC: 1762 CDH3 Cadherin 3, type 1, P-cadherin (placental) 16q22.15.49
ENSG00000166869 CHP2 Calcineurin B homologous protein 2 16p12.2−6.23
HGNC: 1973CHST5 Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 516q22.3−3.83
HGNC: 2015CLCA1 Chloride channel accessory 1 1p22.3−5.68
HGNC: 2018 CLCA4 Chloride channel accessory 4 1p31-p22−4.08
HGNC: 2032 CLDN1 Claudin 1 3q28-q295.36
HGNC: 2050 CLDN8 Claudin 821q22.11−3.69
HGNC: 2311 CPM Carboxypeptidase M12q14.3−3.64
HGNC: 26133CWH43 Cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)4p11−4.59
HGNC: 2765 DEFA6 Defensin, alpha 6, Paneth cell-specific8p23.15.95
HGNC: 3178 EDN3 Endothelin 3 20q13.2-q13.3−4.27
HGNC: 23117FAM55D Family with sequence similarity 55, member D11q23.2−6.18
HGNC: 13572 FCGBP Fc fragment of IgG binding protein 19q13.1−5.52
HGNC: 4128GALNT6 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)12q133.56
HGNC: 4191GCG Glucagon2q36-q37−6.1
HGNC: 4682GUCA2A Guanylate cyclase activator 2A (guanylin)1p35-p34−4.32
HGNC: 4683 GUCA2B Guanylate cyclase activator 2B (uroguanylin)1p34-p33−6.62
HGNC: 4764H3F3A H3 histone, family 3A1q41−3.86
HGNC: 5141 HP Haptoglobin16q22.111.72
HGNC: 6019IL6R Interleukin 6 receptor1q21−3.46
HGNC: 29213 KIAA1199 KIAA1199 15q244.43
HGNC: 6359 KLK11 Kallikrein-related peptidase 1119q13.334.65
HGNC: 7174MMP7 Matrix metallopeptidase 7 (matrilysin, uterine)11q21-q226.75
HGNC: 13370MS4A12 Membrane-spanning 4-domains, subfamily A, member 1211q12−10.66
HGNC: 14296 MT1M Metallothionein 1M 16q13−3.94
HGNC: 7512 MUC2 Mucin 2, oligomeric mucus/gel-forming11p15.5−7.23
HGNC: 7783NFE2L3 Nuclear factor (erythroid-derived 2)-like 37p15.23.02
HGNC: 7978 NR3C1 Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)5q31.3−3.2
HGNC: 7979 NR3C2 Nuclear receptor subfamily 3, group C, member 24q31.1−5.08
HGNC: 8062 NUP153 Nucleoporin 153kDa 6p22.35.9
HGNC: 9748 PYY Peptide YY 17q21.1−4.35
HGNC: 10600 SCNN1B Sodium channel, nonvoltage-gated 1, beta16p12.2-p12.1−3.28
HGNC: 3018 SLC26A3 Solute carrier family 26, member 37q31−5.59
HGNC: 25355 SLC30A10 Solute carrier family 30, member 10 1q41−5.69
HGNC: 11030 SLC4A4 Solute carrier family 4, sodium bicarbonate cotransporter, member 44q21−5.14
HGNC: 11063 SLC7A5 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 516q24.34.05
HGNC: 11242 SPIB Spi-B transcription factor (Spi-1/PU.1 related) 19q13.3-q13.4−4.24
HGNC: 15464 SPINK5 Serine peptidase inhibitor, Kazal type 55q32−4.31
HGNC: 11255 SPP1 Secreted phosphoprotein 14q22.19.69
HGNC: 11329 SST Somatostatin3q28−5.84
HGNC: 11652 TCN1 Transcobalamin I (vitamin B12 binding protein, R binder family)11q11-q128.66
HGNC: 11799THRB Thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) 3q24.2−4.25
HGNC: 17995 TRPM6 Transient receptor potential cation channel, subfamily M, member 69q21.13−4.85
HGNC: 30961 ZG16 Zymogen granule protein 16 homolog (rat)16q11.2−3.94

equation: fold change = ; : the average gene expression in colorectal tumors; : the average gene expression in normal mucosal tissues.