Impact of Serum Biomarkers and Clinical Factors on Intensive Care Unit Mortality and 6-Month Outcome in Relatively Healthy Patients with Severe Pneumonia and Acute Respiratory Distress Syndrome
Table 2
Serum biomarkers characteristics between ICU survivors and nonsurvivors.
ICU survivors (n = 40)
ICU nonsurvivors (n = 16)
P
CRP (mg/L)
Day 1
184.68 ± 106.53
179.71 ± 73.53
0.865
Day 3
102.77 ± 69.01
239.66 ± 67.06
<0.001
Day 3 : day 1
0.91 ± 2.01
1.62 ± 1.15
0.184
PCT (ng/mL)
Day 1
8.29 ± 8.68
9.48 ± 8.32
0.639
Day 3
5.98 ± 11.952
8.37 ± 6.38
0.453
Day 3 : day 1
2.67 ± 9.38
1.05 ± 0.48
0.496
D-dimer (mg/L)
Day 1
4.08 ± 2.07
5.58 ± 2.87
0.034
Day 3
4.07 ± 4.12
5.56 ± 2.45
0.167
Day 3 : day 1
1.28 ± 2.13
1.31 ± 1.23
0.945
Lactate (mg/dL)
Day 1
22.21 ± 9.67
5.58 ± 2.87
0.235
Day 3
16.03 ± 7.69
32.34 ± 27.80
0.001
Day 3 : day 1
0.83 ± 0.50
1.86 ± 3.38
0.061
Albumin (g/dL)
Day 1
2.56 ± 0.49
2.45 ± 0.39
0.416
Day 3
2.59 ± 0.47
2.36 ± 0.35
0.080
Day 3 : day 1
1.02 ± 0.13
0.97 ± 0.11
0.195
HMGB1 (pg/mL)
Day 1
1614.14 ± 641.11
2108.51 ± 574.51
0.025
Day 3
1548.81 ± 650.96
1952.45 ± 763.77
0.010
Day 3 : Day 1
1.02 ± 0.39
1.00 ± 0.52
0.908
IL-8 (pg/mL)
Day 1
56.24 ± 38.10
173.18 ± 304.77
0.019
Day 3
48.27 ± 22.45
97.19 ± 44.29
<0.001
Day 3 : Day 1
1.12 ± 0.79
0.97 ± 0.42
0.472
IL-10 (pg/mL)
Day 1
40.01 ± 35.10
49.08 ± 66.91
0.509
Day 3
39.15 ± 35.56
39.27 ± 28.05
0.990
Day 3 : Day 1
1.16 ± 0.83
1.28 ± 0.63
0.616
Continuous variables were analyzed by Student’s t-test or Mann-Whitney U test, and categorical data by Chi-square test.
bICU: intensive care unit; CRP: c-reactive protein; PCT: procalcitonin; HMGB1: high-mobility group protein B1; and IL: interleukin.
cVariables are expressed as mean (standard deviation) and categorical data are expressed as number (percentage).
