Review Article
Two Polymorphisms in the Fractalkine Receptor CX3CR1 Gene Influence the Development of Atherosclerosis: A Meta-Analysis
Table 1
Characteristics of studies included in this meta-analysis.
| | Position | First author | Year | Country | Study type | Disease | Source of control | SS (Case/Control) | Genotypes distribution (case/control) | HWE
Y/N () | Score | | T/T | T/M | M/M | T | M |
| | T280M | Moatti [15] | 2001 | France | CCS | CAD | HB | 151/249 | 123/179 | 25/65 | 3/5 | 271/423 | 31/75 | Y (0.748) | 8 | | Gugl [8] | 2003 | Austria | CCS | PAD | HB | 492/503 | 333/326 | 143/165 | 16/12 | 809/817 | 175/189 | Y (0.093) | 8 | | Ghilardi [7] | 2004 | Italia | CCS | CAA | HB | 108/204 | 87/142 | 18/58 | 3/4 | 192/342 | 24/66 | Y (0.490) | 8 | | Lavergne [10] | 2005 | France | CCS | CI | HB | 460/469 | 314/338 | 125/123 | 21/8 | 753/799 | 167/139 | Y (0.400) | 7 | | Niessner [17, 18] | 2005 | Austria | CCS | CAD | HB | 720/432 | 514/319 | 189/100 | 17/13 | 1217/738 | 223/126 | Y (0.141) | 7 | | Apostolakis [43] | 2007 | Greece | CCS | CAD | HB | 210/165 | 159/109 | 48/53 | 3/3 | 366/271 | 54/59 | Y (0.228) | 7 | | An [24] | 2008 | China | CCS | CAD | HB | 108/80 | 88/59 | 18/20 | 2/1 | 194/138 | 22/22 | Y (0.629) | 6 | | Nassar-a [16] | 2008 | Canada | CCS | CAD | PB | 149/149 | 97/94 | 49/48 | 3/7 | 243/236 | 55/62 | Y (0.784) | 8 | | Nassar-b [16] | 2008 | Canada | CCS | CAD | PB | 150/149 | 92/94 | 49/48 | 9/7 | 233/236 | 67/62 | Y (0.784) | 8 | | Peng [25] | 2008 | China | CCS | ICVD | PB | 165/150 | 138/143 | 25/7 | 2/0 | 301/293 | 29/7 | Y (0.770) | 8 | | Zheng [31] | 2008 | China | CCS | CAA | HB | 117/93 | 77/73 | 32/17 | 8/3 | 186/163 | 48/23 | Y (0.131) | 6 | | Kimouli [9] | 2009 | Greece | CCS | CAA | PB | 150/151 | 112/87 | 31/58 | 7/6 | 255/232 | 45/70 | Y (0.334) | 8 | | Matzhold [12] | 2009 | Austria | CCS | CAD | PB | 2565/728 | 1797/483 | 706/217 | 59/26 | 4300/1183 | 824/269 | Y (0.790) | 7 | | Xiao [28] | 2010 | China | CCS | CAD | PB | 139/90 | 129/81 | 10/9 | 0/0 | 268/171 | 10/9 | Y (0.618) | 7 | | Zhang [30] | 2010 | China | CCS | CI | PB | 120/102 | 98/71 | 20/30 | 2/1 | 216/172 | 24/32 | Y (0.258) | 7 | | Zhao [23] | 2010 | China | CCS | CAA | HB | 318/292 | 246/201 | 56/70 | 16/21 | 548/472 | 88/112 | N (0.000) | 7 | | Li [11] | 2012 | China | CCS | CI | PB | 308/294 | 284/280 | 24/14 | 0/0 | 592/574 | 24/14 | Y (0.676) | 8 | | Shi [26] | 2012 | China | CCS | CI | HB | 563/563 | 493/518 | 50/38 | 20/7 | 1036/1074 | 90/52 | N (0.000) | 7 | | Singh-a [21, 22] | 2012 | India | CCS | CAD | PB | 152/300 | 126/191 | 24/99 | 2/10 | 276/481 | 28/119 | Y (0.513) | 8 | | Singh-b [21, 22] | 2012 | India | CCS | CAD | PB | 156/300 | 124/191 | 28/99 | 4/10 | 276/481 | 36/119 | Y (0.513) | 8 | | Singh-c [21, 22] | 2012 | India | CCS | AMI | PB | 230/300 | 190/191 | 36/99 | 4/10 | 416/481 | 44/119 | Y (0.513) | 7 | | Wu [27] | 2012 | China | CCS | IS | PB | 163/100 | 135/95 | 26/5 | 2/0 | 296/195 | 30/5 | Y (0.798) | 7 | | Pucci-a [19] | 2013 | Italy | CCS | AMI | HB | 25/22 | 21/14 | 4/7 | 0/1 | 46/35 | 4/9 | Y (0.917) | 7 | | Pucci-b [19] | 2013 | Italy | CCS | AMI | HB | 16/22 | 9/14 | 7/7 | 0/1 | 25/35 | 7/9 | Y (0.917) | 7 |
| | Position | First
author | Year | Country | Study type | Disease | Source of control | SS (case/control) | Genotypes distribution (case/control) | HWE
Y/N () | Score | | V/V | V/I | I/I | V | I |
| | V249I | Moatti [15] | 2001 | France | CCS | CAD | HB | 151/249 | 97/126 | 47/104 | 7/19 | 241/356 | 61/142 | Y (0.699) | 8 | | Gugl [8] | 2003 | Austria | CCS | PAD | HB | 492/503 | 261/268 | 198/210 | 33/25 | 720/746 | 264/260 | N (0.045) | 8 | | Ghilardi [7] | 2004 | Italia | CCS | CAA | HB | 108/204 | 63/108 | 34/84 | 11/12 | 160/300 | 56/108 | Y (0.409) | 8 | | Lavergne [10] | 2005 | France | CCS | CI | HB | 458/468 | 234/236 | 178/203 | 46/29 | 646/675 | 270/261 | Y (0.089) | 7 | | Niessner [17, 18] | 2005 | Austria | CCS | CAD | HB | 720/432 | 395/246 | 271/161 | 54/25 | 1061/653 | 379/211 | Y (0.842) | 7 | | Rios [20] | 2005 | Brazil | CS | CAD | HB | 219/129 | 120/72 | 80/51 | 19/6 | 320/195 | 118/63 | Y (0.420) | 7 | | Apostolakis [43] | 2007 | Greece | CCS | CAD | HB | 210/165 | 111/86 | 81/59 | 18/20 | 303/231 | 117/99 | Y (0.056) | 7 | | An [24] | 2008 | China | CCS | CAD | HB | 108/80 | 70/41 | 33/34 | 5/5 | 173/116 | 43/44 | Y (0.556) | 6 | | Nassar-a [16] | 2008 | Canada | CCS | CAD | PB | 149/149 | 73/63 | 63/69 | 13/17 | 209/195 | 89/103 | Y (0.772) | 7 | | Nassar-b [16] | 2008 | Canada | CCS | CAD | PB | 150/149 | 58/63 | 77/69 | 15/17 | 193/195 | 107/103 | Y (0.772) | 8 | | Zhang [29] | 2008 | China | CCS | ICVD | PB | 165/150 | 122/132 | 40/18 | 3/0 | 284/282 | 46/18 | Y (0.434) | 8 | | Zheng [31] | 2008 | China | CCS | CAA | HB | 117/93 | 69/53 | 33/32 | 15/8 | 171/138 | 63/48 | Y (0.328) | 6 | | Kimouli [9] | 2009 | Greece | CCS | CAA | PB | 150/151 | 82/73 | 59/64 | 9/14 | 223/210 | 77/92 | Y (0.996) | 8 | | Matzhold [12] | 2009 | Austria | CCS | CAD | PB | 2565/728 | 1374/372 | 1012/283 | 179/73 | 3760/1027 | 1370/429 | Y (0.081) | 7 | | Xiao [28] | 2010 | China | CCS | CAD | PB | 139/90 | 126/68 | 13/19 | 0/3 | 265/155 | 13/25 | Y (0.265) | 7 | | Zhang [30] | 2010 | China | CCS | CI | PB | 120/102 | 81/51 | 35/43 | 4/8 | 197/145 | 43/59 | Y (0.798) | 7 | | Zhao [23] | 2010 | China | CCS | CAA | HB | 318/292 | 194/164 | 66/65 | 58/63 | 454/393 | 182/191 | N (0.000) | 7 | | Li [11] | 2012 | China | CCS | CI | PB | 308/294 | 289/280 | 19/14 | 0/0 | 597/574 | 19/14 | Y (0.676) | 8 | | Shi [26] | 2012 | China | CCS | CI | HB | 563/563 | 497/512 | 52/44 | 14/7 | 1046/1068 | 80/58 | N (0.000) | 7 | | Singh-a [21, 22] | 2012 | India | CCS | CAD | PB | 152/300 | 111/150 | 37/118 | 4/32 | 259/418 | 45/182 | Y (0.230) | 8 | | Singh-b [21, 22] | 2012 | India | CCS | CAD | PB | 156/300 | 96/150 | 48/118 | 12/32 | 240/418 | 72/182 | Y (0.230) | 8 | | Singh-c [21, 22] | 2012 | India | CCS | AMI | PB | 230/300 | 157/150 | 61/118 | 12/32 | 375/419 | 85/182 | Y (0.230) | 7 | | Wu [27] | 2012 | China | CCS | IS | PB | 163/100 | 119/88 | 41/12 | 3/0 | 279/188 | 47/12 | Y (0.523) | 7 | | Pucci-a [19] | 2013 | Italy | CCS | AMI | HB | 25/22 | 13/2 | 10/12 | 2/8 | 36/16 | 14/28 | Y (0.402) | 7 | | Pucci-b [19] | 2013 | Italy | CCS | AMI | HB | 16/22 | 1/2 | 10/12 | 5/8 | 12/16 | 20/28 | Y (0.402) | 7 |
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CCS: case-control study, CS: cohort study, SS: sample size, PB: population-based, HB: hospital-based, HWE: Hardy-Weinberg equilibrium, Y: yes, N: no, AMI: acute myocardial infarction, CAA: carotid artery atherosclerosis, CAD: coronary artery disease, CI: cerebral infarction, ICVD: ischemic cerebrovascular disease, IS: ischemic stroke, PAD: peripheral arterial disease.
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