Stepwise Application of Urine Markers to Detect Tumor Recurrence in Patients Undergoing Surveillance for Non-Muscle-Invasive Bladder Cancer

Table 4

(a) Performance of stepwise testing of cytology and uCyt+. High-risk tumors were defined as tumors showing at least one of the following features: pT1 or higher, G3, carcinoma in situ (Cis). PPV: positive predictive value. NPV: negative predictive value. (b) Performance of stepwise testing of cytology and fluorescence in situ hybridization (FISH). High-risk tumors were defined as tumors showing at least one of the following features: pT1 or higher, G3, carcinoma in situ (Cis). PPV: positive predictive value. NPV: negative predictive value.

(a)

Combination positive ()/negative ()/specificity (%)	230/253/64.2%
Tumors detected ()/sensitivity (%)	103/80.5%
High-risk tumors detected ()/sensitivity (%)	47/94%
Numbers of tumors missed ()/NPV (%)	25/90.1%
Numbers of high-risk tumors missed ()/NPV (%)	3/98.8%
Numbers of false positive tests ()/PPV (%)	127/44.7%
Additional tumors detected ()/additional high-risk tumors detected by uCyt+ ()	14/4

(b)

Combination positive ()/negative ()/specificity (%)	231/252/59.5%
Tumors detected ()/sensitivity (%)	108/84.4%
High-risk tumors detected ()/sensitivity (%)	46/92.0%
Numbers of tumors missed ()/NPV (%)	20/91.3%
Numbers of high-risk tumors missed ()/NPV (%)	4/98.8%
Numbers of false positive tests ()/PPV (%)	144/42.8%
Additional tumors detected ()/additional high-risk tumors detected ()	19/3