Association of FTO Mutations with Risk and Survival of Breast Cancer in a Chinese Population
Table 2
ORs and 95% CIs for breast cancer in relation to polymorphisms of FTO gene.
SNP
Genotypes
Cases, (%)
Controls, (%)
OR (95% CI)
OR (95% CI)
trend
rs9939609
TT
389 (72.6)
408 (76.0)
1.00
1.00
0.13
TA
130 (24.2)
119 (22.1)
1.14 (0.86–1.52)
1.14 (0.85–1.52)
AA
17 (3.2)
10 (1.9)
1.78 (0.80–3.93)
1.69 (0.75–3.80)
AA + TA
147 (27.4)
129 (24.0)
1.19 (0.90–1.57)
1.18 (0.89–1.56)
rs1477196
GG
272 (50.7)
231 (43.0)
1.00
1.00
0.004
GA
231 (43.1)
254 (47.3)
0.77 (0.60–0.99)
0.79 (0.61–1.02)
AA
33 (6.2)
52 (9.7)
0.54 (0.34–0.86)
0.56 (0.34–0.90)
AA + GA
264 (49.2)
306 (57.0)
0.73 (0.58–0.93)
0.75 (0.59–0.96)
rs6499640
GG
361 (67.5)
375 (69.8)
1.00
1.00
0.44
GA
159 (29.7)
148 (27.6)
1.12 (0.85–1.46)
1.13 (0.86–1.48)
AA
15 (2.8)
14 (2.6)
1.10 (0.52–2.32)
1.11 (0.52–2.35)
AA + GA
174 (32.5)
162 (30.2)
1.11 (0.86–1.44)
1.13 (0.87–1.47)
rs16953002
GG
217 (40.5)
250 (46.5)
1.00
1.00
0.005
GA
232 (43.3)
231 (43.0)
1.16 (0.90–1.50)
1.13 (0.87–1.46)
AA
87 (16.2)
56 (10.4)
1.80 (1.23–2.63)
1.77 (1.20–2.61)
AA + GA
319 (59.5)
287 (53.5)
1.28 (1.01–1.64)
1.25 (0.98–1.60)
rs11075995
TT
249 (46.5)
236 (44.0)
1.00
1.00
0.24
TA
244 (45.5)
247 (46.0)
0.93 (0.73–1.20)
0.97 (0.75–1.25)
AA
43 (8.0)
54 (10.0)
0.75 (0.48–1.17)
0.80 (0.51–1.25)
AA + TA
287 (53.5)
301 (56.0)
0.90 (0.71–1.15)
0.94 (0.73–1.20)
rs1121980
GG
360 (67.2)
377 (70.2)
1.00
1.00
0.19
GA
154 (28.7)
145 (27.0)
1.11 (0.85–1.45)
1.11 (0.84–1.46)
AA
22 (4.1)
15 (2.8)
1.54 (0.79–3.02)
1.42 (0.71–2.82)
AA + GA
176 (32.8)
160 (29.8)
1.15 (0.89–1.49)
1.13 (0.87–1.48)
Adjusted for age. Adjusted for age, age at menarche, BMI, ever breastfeeding, and education. trend is test of trend for the number of copies of the variant allele (0, 1 and 2).
