Secernin-1 Contributes to Colon Cancer Progression through Enhancing Matrix Metalloproteinase-2/9 Exocytosis

Table 4

Cox proportional hazards model univariate and multivariate analyses of individual parameters for correlations with disease-free survival (DFS) in 117 patients.

Variable	Univariate	value	Multivariate	value
	HR (95% CI)		HR (95% CI)
Age
<65 y	—		NR
≥65 y	1.608 (0.732–3.532)	0.237
Gender
Male	—		NR
Female	1.490 (0.711–3.122)	0.290
Location
Right	—
Transverse	0.438 (0.057–3.365)	0.427	NR
Left	0.831 (0.393–1.757)	0.628
T stage
T1 and T2	—		NR
T3 and T4	2.437 (0.737–8.053)	0.144
N stage
N0	—
N1	3.722 (1.440–9.620)	0.007^*	NR
N2	17.423 (6.534–46.460)	<0.001^*
M stage
M0	—		NR
M1	26.601 (10.073–70.248)	<0.001^*
AJCC stage
I and II	—		—
III and IV	5.964 (2.537–14.023)	<0.001^*	5.041 (2.112–12.030)	<0.001^*
Differentiation
Well	—		—
Moderate	2.035 (0.843–4.913)	0.114	1.589 (0.653–3.864)	0.307
Poorly	6.404 (2.521–16.268)	<0.001^*	5.635 (2.143–14.821)	<0.001^*
Vessel invasion
No	—		NR
Yes	3.954 (0.934–16.738)	0.062
SCRN1 expression
Negative and weak	—		—
Moderate and strong	2.328 (1.059–5.114)	<0.035^*	2.262 (1.008–5.078)	<0.048^*

AJCC: American Joint Committee on Cancer; SCRN1: Secernin-1;
HR: hazard ratio; CI: confidence interval. NR variable was not included in the resultant model.
indicated that the 95% CI of HR was not including 1.
^*means significant difference.