Research Article

Albumin-to-Alkaline Phosphatase Ratio: A Novel Prognostic Index for Hepatocellular Carcinoma

Table 3

Univariate and multivariate analyses of prognostic factors in the training cohort.

Prognostic factorOverall survivalDisease-free survival
UnivariateMultivariateUnivariateMultivariate
HR95% CIP valueHR95% CIPvalueHR95% CIP valueHR95% CIP value

Patient factors
 Male gender1.7260.895–3.3320.1041.6350.952–2.8060.075
 Age1.0211.002–1.0400.0271.0150.996–1.0360.1261.0120.996–1.0290.134
 Hepatitis B0.8880.493–1.5970.6910.9530.571–1.5910.855
 Hepatitis C1.3530.495–3.6990.5561.4010.614–3.1980.423
 Cirrhosis1.9211.229–3.0020.0041.9011.194–3.0280.0071.4300.991–2.0630.056
Tumour factors
 Tumour size (cm)1.0061.000–1.0110.0341.0051.000–1.0100.034
 Histological grade4.1251.673–10.1710.0021.1360.752–1.7170.5453.2851.666–6.4800.0011.1070.780–1.5700.570
 Multiple tumours3.1202.021–4.816<0.0012.8851.965–4.236<0.001
 Vascular invasion4.3712.862–6.676<0.0013.1592.181–4.576<0.001
 AJCC stage2.6572.079–3.395<0.0012.2651.719–2.985<0.0012.4001.937–2.972<0.0012.0771.623–2.658<0.001
 BCLC stage1.9381.569–2.393<0.0011.8591.540–2.243<0.001
 CLIP score1.7731.458–2.156<0.0011.7901.500–2.136<0.001
 CUPI score2.0471.130–3.7070.0182.2661.341–3.8300.002
 JIS score2.1421.762–2.604<0.0011.8831.564–2.268<0.001
Blood parameters
 AFP ≥500 μg/L1.8931.244–2.8830.0031.4650.916–2.3410.1111.9851.384–2.847<0.0011.4220.955–2.1180.083
 AAPR (>0.68/0.23–0.68/<0.23)3.3471.966–5.699<0.0012.3571.354–4.1020.0022.4641.550–3.916<0.0011.8521.158–2.9640.010
 MELD2.9511.419–6.1360.0040.9990.894–1.1190.8751.1971.086–1.321<0.0011.0680.964–1.1840.208

Tumour size, multiplicity, vascular invasion, and staging systems with lower -index than AJCC were excluded in the multivariate analyses to minimize multicollinearity.