Monitoring of Serial Presurgical and Postsurgical Changes in the Serum Proteome in a Series of Patients with Calcific Aortic Stenosis

Figure 4

Venn diagrams showing proteins with differential levels in postsurgical and presurgical sera of patients with CAS, AAA, and TAA. The 29 and 35 serum proteins with differential levels in presurgical and postsurgical sera of AAA and TAA patients, respectively, identified in our previous study [12] were compared with the 16 differentially expressed proteins identified in presurgical and postsurgical sera of CAS patients. The Venn diagrams show inclusion and exclusion relations of datasets of each group with iTRAQ ratios (postsurgical versus presurgical) of the identified proteins. Antithrombin-III (SERPINC1) and zinc-α-2-glycoprotein (AZGP1) are emphasized by highlighter colors.