Radiosynthesis, In Vivo Biological Evaluation, and Imaging of Brain Lesions with [¹²³I]-CLINME, a New SPECT Tracer for the Translocator Protein

Figure 6

Measures of relative optical density (ROD) following in vitro autoradiography with 16 nM [¹²⁵I]-CLINME and effect of 20 μM of PK11195, CLINME, or flumazenil (a). Representative autoradiograms showing a region of very high activity in the unilateral dorsal striatum (with extension dorsally into the cortex). Specific binding in the lining of the lateral ventricles can also be observed (b). ipsilateral versus contralateral; versus [¹²⁵I]-CLINME alone.

(a)

(b)