Radiosynthesis, In Vivo Biological Evaluation, and Imaging of Brain Lesions with [¹²³I]-CLINME, a New SPECT Tracer for the Translocator Protein

Figure 7

Immunohistochemistry for glial fibrillary acidic protein (GFAP, green) and anti-CD11b antibody (Ox42) or neuron-specific nuclear protein (NeuN, both red). The arrows indicate a region identified as the excitotoxic lesion, with increased Ox42 staining and decreased NeuN staining indicating microglial activation and neurodegeneration, respectively. LV = lateral ventricle, CC = corpus callosum.