Two tagSNPs rs352493 and rs3760908 within <i>SIRT6</i> Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population

<div>Schematic of<i> SIRT6</i> gene structure and pairwise LD between the five tagSNPs.<i> SIRT6</i> gene consists of 8 exons (boxes, E1~E8) separated by 7 introns and spans a region of 8,427 bp. Filled boxes indicate the coding regions. The arrows indicate the locations of single nucleotide polymorphism. <svg height="11.4859pt" id="M8" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.4361 13.8905 11.4859" width="13.8905pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M743 375C743 570 607 650 407 650H136L130 622C214 612 220 606 204 526L125 122C110 43 105 36 24 27L17 0H250C382 0 482 23 571 76C680 141 743 248 743 375ZM644 379C644 188 520 36 305 36C277 36 249 38 229 46C205 55 202 71 212 126L293 553C300 588 306 600 317 606C330 613 356 617 390 617C547 617 644 537 644 379Z" id="g113-69"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="766" vert-adv-y="766"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,9.958,-5.741)"><path d="M310 541L304 571C290 586 211 619 185 610L80 76L131 52L310 541Z" id="g50-31"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="361" vert-adv-y="361"></glyph.data></g></svg> values are plotted as a graph to show linkage disequilibrium between the five tagSNPs.</div>

Disease Markers

fig1

Figure 1

Figure 1: Two tagSNPs rs352493 and rs3760908 within <i>SIRT6</i> Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population 

Figure 1 | Two tagSNPs rs352493 and rs3760908 within SIRT6 Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population 