Prognostic and Predictive Values of Subcellular Localisation of RET in Renal Clear-Cell Carcinoma

Table 1

Clinical characteristics of patients.

Features	RET cytoplasm			RET nuclear
	Low expression ()	High expression ()	value	Low expression ()	High expression ()	value
Median age (years)	56 (29–81, 46–63)	52 (18–79, 45–62)		54 (18–81, 45–63)	56 (21–79, 47–65)
Gender (male)	107 (79%)	97 (71%)	0.256	110 (76%)	94 (73%)	0.931
Median PFS months	26 (1.5–>102, 10.8–>55)	12 (1–>93, 5.8–>36)	<0.001^†	26 (1.5–102, 9.3–>65)	13.1 (1–>93, 6–>47)	0.002^†
Median OS months	>36 (2–>102, >25.1–>44.5)	28 (1–>93, 13.1–>47)	<0.001^†	49 (2–102, 21.4–>65)	31.5 (1–>93, 14.2–>52)	0.007^†
ECOG PS
0	69	63	0.151	78	56	0.233
≥1	67	74		66	73
T stage
1-2	90	78	0.083	89	79	0.907
3-4	46	59		55	50
Metastasis status
No	59	56	0.100	68	47	<0.001
Yes	77	81		76	82
Fuhrman grade
1-2	87	81	0.144	90	78	0.208
3-4	49	56		54	51

Data are median (range, IQR) or (%). PFS and OS were deemed as continuous variable, and Spearman’s Rho test was used to study the relationships between the covariates. ^†PFS and OS were deemed as dichotomized variable, and log-rank test was used to study the differences between the covariates.