Prognostic and Predictive Values of Subcellular Localisation of RET in Renal Clear-Cell Carcinoma
Table 2
Multivariable Cox regression analyses.
Multivariable Cox regression
Association with PFS
Association with OS
value
HR
95% CI
value
HR
95% CI
(A) RET cytoplasmic continuous
Fuhrman grade
0.003
1.408
1.120–1.770
0.039
1.292
1.014–1.646
ECOG PS
<0.001
1.766
1.419–2.199
<0.001
1.921
1.521–2.428
T stage
0.011
1.275
1.057–1.538
0.026
1.242
1.026–1.503
Metastasis
<0.001
2.775
1.791–4.298
<0.001
3.143
1.998–4.944
Targeted treatment
0.001
0.518
0.349–0.769
<0.001
0.407
0.270–0.613
RET continuous
<0.001
1.860
1.459–2.372
<0.001
1.666
1.306–2.125
(B) RET nuclear continuous
Fuhrman grade
0.003
1.408
1.123–1.765
0.039
1.287
1.012–1.636
ECOG PS
<0.001
1.842
1.470–2.308
<0.001
1.999
1.573–2.541
T stage
0.024
1.244
1.029–1.503
0.043
1.220
1.006–1.480
Metastasis
<0.001
2.671
1.697–4.203
<0.001
3.097
1.930–4.970
Targeted treatment
0.002
0.526
0.351–0.790
<0.001
0.419
0.275–0.639
RET nuclear continuous
0.004
1.379
1.109–1.716
0.047
1.260
1.003–1.584
(C) RET cytoplasmic dichotomized
RET cytoplasmic (high versus low)
0.001
1.683
1.235–2.293
0.003
1.635
1.185–2.255
(D) RET nuclear dichotomised
RET nuclear (high versus low)
0.020
1.428
1.058–1.927
0.307
1.180
0.859–1.623
(E) Multivariable Cox regression (combined RET cytoplasmic and nuclear expression)
Low RET nuclear and cytoplasmic
reference
High RET nuclear only
0.028
1.713
1.059–2.772
0.083
1.568
0.943–2.608
High RET cytoplasmic only
0.220
1.366
0.830–2.248
0.136
1.507
0.879–2.582
High RET nuclear and cytoplasmic
<0.001
2.466
1.639–3.711
<0.001
2.294
1.499–3.510
Covariates are not showed for the omitted space; comparisons of dichotomized variable. HR, hazard ratio; CI, confidence interval; ECOG PS, Eastern Cooperative Oncology Group performance status.
