KIF2A Overexpression and Its Association with Clinicopathologic Characteristics and Poor Prognoses in Patients with Gastric Cancer

Table 2

Association of high expression of KIF2A with clinicopathological characteristics in gastric cancer patients.

Characteristic		KIF2A−	KIF2A+	Pearson
Total	461
Gender				1.1992	0.273
Male	344	116 (33.72)	228 (66.28)
Female	117	46 (39.32)	71 (60.28)
Age				5.3135	0.021
<60	156	66 (42.31)	90 (57.69)
≧60	305	96 (31.48)	209 (68.52)
Histological type				10.0769	0.039
Tubular	384	128 (33.38)	256 (66.67)
Mixed (tubular and mucinous)	17	6 (35.29)	11 (64.71)
Mucinous	25	10 (40.00)	15 (60.00)
Signet ring cell	15	11 (73.33)	4 (26.67)
Others	20	8 (40.00)	12 (60.00)
Differentiation				1.8888	0.169
Well and middle	143	43 (30.07)	100 (69.93)
Poor	280	103 (36.79)	177 (63.21)
Others	38	16	22
TNM stage				17.5014	0.008
Ia	37	21 (56.76)	16 (43.24)
Ib	52	21 (40.38)	31 (59.62)
IIa	102	43 (42.16)	59 (57.84)
IIb	67	22 (32.84)	45 (67.16)
IIIa	83	26 (31.33)	57 (68.67)
IIIb	77	18 (23.38)	59 (76.62)
IIIc + IV	43	11 (25.58)	32 (74.42)
T				5.7839	0.123
Tis	9	6 (66.67)	3 (33.33)
T1	41	20 (48.78)	21 (51.22)
T2	94	32 (34.04)	62 (65.96)
T3 + T4	317	117 (36.91)	200 (63.09)
N				11.5439	0.009
N0	176	77 (43.75)	99 (56.25)
N1	89	31 (34.83)	58 (65.17)
N2	94	29 (30.85)	65 (69.15)
N3	102	25 (24.51)	77 (75.49)
M				2.5075	0.113
M0	426	154 (36.15)	272 (63.85)
M1	35	8 (22.86)	27 (77.14)
Preoperative CEA, ng/mL				2.6563	0.103
≦5	185	73 (39.46)	112 (60.54)
>5	61	17 (27.87)	44 (72.13)
Unknown	215	72	143
Preoperative CA199, U/mL				0.1195	0.730
≦37	200	74 (37.00)	126 (63.00)
>37	41	14 (34.15)	27 (65.85)
Unknown	220	74	146

< 0.05; others: papillary adenocarcinoma, 3 cases; adenosquamous carcinoma, 3 cases; squamous cell carcinoma, 3 cases; undifferentiated carcinoma, 1 case; small cell malignant tumor, 8 cases; carcinoid, 1 case; focal cancer, 1 case.
others: besides tubular and papillary adenocarcinoma.