KIF2A Overexpression and Its Association with Clinicopathologic Characteristics and Poor Prognoses in Patients with Gastric Cancer

Table 3

Univariate and multivariate analysis of prognostic factors for overall survival in gastric cancer patients.

	Univariate analysis				Multivariate analysis
	HR	>	95% CI		HR	>	95% CI
KIF2A expression
High versus low	0.334	<0.001	0.246	0.453	0.366	<0.001	0.268	0.500
Age (years)
≤60 versus >60	1.402	0.012	1.077	1.827	1.231	0.140	0.934	1.622
Gender
Male versus female	1.042	0.777	0.786	1.381
Histological type
Tubular versus mixed (tubular and mucinous) versus Mucinous versus	1.015	0.860	0.856	1.205
signet ring cell carcinoma versus others
Differentiation
Well versus middle versus poor	1.380	0.001	1.146	1.661	1.229	0.046	1.004	1.505
TNM stage
0 versus Ia versus Ib versus IIa versus IIb versus IIIa versus IIIb versus IIIc and versus IV	1.563	<0.001	1.444	1.691	1.324	0.002	1.113	1.575
T
Tis versus T1 versus T2 versus T3 + T4	1.079	0.113	0.982	1.185
N
N0 versus N1 versus N2 versus N3	1.648	<0.001	1.483	1.833	1.183	0.096	0.971	1.441
M
M0 versus M1	3.167	<0.001	2.518	4.646	1.741	0.102	0.896	3.383
Preoperative CEA (ng/mL)
≤5 versus ≥5	1.136	0.053	0.998	1.293
Preoperative CA199 (U/mL)
≤37 versus >37	1.102	0.129	0.972	1.251

< 0.05; others: papillary adenocarcinoma, 3 cases; adenosquamous carcinoma, 3 cases; squamous cell carcinoma, 3 cases; undifferentiated carcinoma, 1 case; small cell malignant tumor, 8 cases; carcinoid, 1 case; focal cancer, 1 case.