Phosphorylated mTOR Expression Profiles in Human Normal and Carcinoma Tissues

Table 1

Expression of p-mTOR in normal human fetal and adult tissues.

Organ	Cell type	p-mTOR
		Fetus	Adult
Stomach	Foveolar epithelium	+	+
	Glands	±	±
Bowel	Crypt	+++	+++
	Mesothelial cell	+++	+++
	Myenteric plexus (ganglion)	+	++
	Myenteric plexus (myelin sheath)	+	+
Liver	Hepatocyte	−	−
	Bile duct	+++	+++
Pancreas	Islet	−	−
	Acinar	−	−
	Centroacinar	+++	+++
	Duct	+++	+++
Kidney	Bowman’s capsule	±	±
	Proximal tubule	±	±
	Distal tubule	+++	+++
	Collecting duct	+++	+++
Bladder	Urothelium (umbrella cell)	+++	+++
	(basal to intermediate cell)	−	+
Lung	Bronchial epithelium	±	++
	Pneumocyte	+++	±
Brain	Neuron	+(n)	±
	Neuroglia (nonependymal cell)	±	±
	Ependymal cell	+++	NA
	Choroid plexus	++	++
Skin	Squamous epithelium	NA	+(n)
	Sweat gland	NA	+

−: undetectable; ±: <5% positive cells; +: mild intensity in most cells; ++: moderate intensity in most cells; +++: strong intensity in most cells; (n): nuclear staining; NA: not available.