Disease Markers

Research Article

Association of Circulating IGFBP1 Level with the Severity of Coronary Artery Lesions in Patients with Unstable Angina

Table 1

Basic characteristics of the enrolled subjects.


	Noncritical CAD ()	Critical CAD ()	value

Age, year	60.11 ± 9.91	62.16 ± 11.08	0.318
Gender, male, n (%)	16 (35.60)	50 (74.60)	<0.001
BMI, kg/m²	23.03 ± 2.23	24.28 ± 3.03	0.019
Cigarette smoking, n (%)	12 (26.70)	36 (53.70)	0.005
Hypertension, n (%)	21 (46.70)	33 (49.30)	0.788
SBP, mmHg	132.98 ± 15.91	132.28 ± 19.72	0.844
DBP, mmHg	78.40 ± 10.74	75.37 ± 11.65	0.167
Hyperlipidemia	16 (35.60)	19 (28.40)	0.420
TC, mmol/L	4.39 ± 0.98	4.05 ± 0.96	0.070
TG, mmol/L	1.22 (0.87, 1.64)	1.27 (1.00, 1.76)	0.251
ApoB, g/L	0.78 ± 0.22	0.76 ± 0.20	0.781
HDL-C, mmol/L	1.22 ± 0.28	1.02 ± 0.25	<0.001
LDL-C, mmol/L	2.66 ± 0.76	2.48 ± 0.68	0.183
Medication
Antiplatelets, (%)	31 (68.90)	64 (95.50)	<0.001
ACEIs or ARBs, (%)	26 (57.80)	49 (73.10)	0.090
β-blockers, (%)	31 (68.90)	45 (67.20)	0.848
CCB, (%)	14 (31.10)	8 (11.90)	0.012
Statins, (%)	31 (68.90)	64 (95.50)	<0.001
Diuretics, (%)	6 (13.30)	8 (11.90)	0.827
Glucose, mmol/L	4.75 ± 0.64	4.69 ± 0.58	0.601
BNP, pg/ml	16.10 (6.55, 25.50)	46.60 (15.40; 85.00)	<0.001
IGFBP-1, ng/ml	10.02 (5.82; 12.98)	16.12 (8.74; 33.20)	<0.001

CAD: coronary artery disease; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; TG: total triglyceride; ApoB: apolipoprotein B; HDL-C: high density lipoprotein cholesterol; LDL-C: low density lipoprotein cholesterol; ACEIs: angiotensin-converting enzyme inhibitors; ARBs: angiotensin receptor blockers; CCB: calcium channel blockers; BNP: brain natriuretic peptide; IGFBP-1: insulin-like growth factor binding protein-1.