Eg5 Overexpression Is Predictive of Poor Prognosis in Hepatocellular Carcinoma Patients

Table 3

Univariate and multivariate analyses of prognostic factors for overall survival in liver cancer patients.

	Univariate analysis				Multivariate analysis
	HR	p > |z|	95% CI		HR	p > |z|	95% CI
Eg5 expression
High versus low	4.490	<0.001	2.511	8.030	3.913	<0.001	2.136	7.167
Age (years)
≤60 versus >60	0.983	0.949	0.589	1.643
Gender
Male versus female	0755	0.260	0.463	1.323
Liver cirrhosis
Yes versus no	2.396	0.003	1.339	4.286	2.169	0.009	1.210	3.889
Gross classification
Solitary versus multiple	2.292	0.007	1.254	4.188
Differentiation
Well versus middle versus poor	1.217	0.353	0.804	1.843
Hepatitis B viral infection
Yes versus no	1.489	0.438	0.544	4.072
Vascular invasion
Yes versus no	1.132	0.582	0.728	1.761
Tumor diameter (cm)
<5 versus ≥5	1.287	0.277	0.816	2.029
TNM stage
I versus II versus III	1.604	0.011	1.112	2.313	1.524	0.025	1.053	2.206
Preoperative α-fetoprotein (ng/ml)
<20 versus ≥20	0.900	0.658	0.564	1.436

; HR: hazard ratio; 95% CI: 95% confidence interval.