Research Article
The Prognostic Value of Decreased KLF4 in Digestive System Cancers: A Meta-Analysis from 17 Studies
Table 2
Subgroup analysis of loss of KLF4 expression for OS and DFS/RFS/MFS in digestive system cancers.
| | Outcome | Variables | Number of studies | Model | HR (95% CI) | Heterogeneity | | I2 (%) | value |
| | OS | | 15 | Random | 1.61 (1.17–2.20) | 78.20% | 0.001 | | Cancer type | | | CRC | 5 | Random | 1.17 (1.01–1.37) | 76.80% | 0.002 | | GC | 3 | Fixed | 1.97 (1.36–2.83) | 0.00% | 0.646 | | HCC | 3 | Random | 2.30 (1.35–3.92) | 87.10% | 0.001 | | ESCC | 2 | Random | 0.84 (0.58–1.22) | 70.40% | 0.066 | | PDAC | 2 | Fixed | 2.70 (1.75–4.17) | 0.00% | 0.853 | | Ethnicity | | | Caucasian | 3 | Random | 1.17 (1.00–1.38) | 71.10% | 0.032 | | Asian | 12 | Random | 1.54 (1.28–1.84) | 79.00% | 0.001 | | Method | | | IHC | 12 | Random | 1.38 (1.21–1.57) | 75.80% | 0.001 | | RT-PCR | 3 | Random | 0.93 (0.62–1.39) | 87.00% | 0.001 | | DFS/MFS/RFS | | 7 | Random | 1.99 (1.12–3.52) | 72.50% | 0.001 | | Cancer type | | | CRC | 2 | Fixed | 1.83 (1.14–2.94) | 0.00% | 0.559 | | HCC | 3 | Random | 2.20 (1.43–3.39) | 90.40% | 0.001 | | GC | 1 | — | 2.14 (1.04–4.41) | — | — | | PDAC | 1 | — | 2.60 (1.02–6.63) | — | — | | Ethnicity | | | Caucasian | 2 | Random | 0.59 (0.36–0.94) | 72.50% | 0.001 | | Asian | 5 | Random | 1.91 (1.23–2.96) | 81.00% | 0.001 | | Method | | | IHC | 6 | Fixed | 2.43 (1.82–3.25) | 13.00% | 0.332 | | RT-PCR | 1 | — | 0.25 (0.09–0.73) | — | — |
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CRC: colorectal cancer; GC: gastric cancer; HCC: hepatocellular carcinoma; ESCC: esophageal squamous cell carcinoma; PDAC: pancreatic ductal adenocarcinoma; IHC: immunohistochemistry; RT-PCR: real-time polymerase chain reaction.
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