Growth Differentiation Factor-15 as a Predictor of Idiopathic Membranous Nephropathy Progression: A Retrospective Study

Figure 4

Kaplan-Meier analysis of renal survival on GDF-15 and PLA₂R Ab. Kaplan-Meier curve (a) for the occurrence of disease progression (log-rank ) showed a significant difference between groups 1 and 2. (b) Patients in group 2 showed higher ΔeGFR/year than patients in group 1 (). Kaplan-Meier curve (c) for the occurrence of disease progression (log-rank ) also showed a significant difference between patients with PLA₂R Ab ≥ 2.77 ng/ml and patients with PLA₂R Ab < 2.77 ng/ml. (d) Patients with PLA₂R Ab ≥ 2.77 (ng/ml) showed higher ΔeGFR/year than patients with PLA₂R Ab < 2.77 (ng/ml) (). GDF: growth differentiation factor; slope of ΔeGFR: (final eGFR − initial eGFR)/6; PLA₂R Ab: phospholipase A₂ receptor antibody.

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