Circulating Semaphorin 4D as a Marker for Predicting Radiographic Progression in Patients with Rheumatoid Arthritis

Table 1

Baseline characteristics of study population.

Characteristics	RA ()	Control ()	value
Female sex	111	56	—
Age (years, mean ± standard deviation)	52.9 ± 11.9	52.7 ± 12.0	—
ESR (mm/hr)	20 (10–38)	5 (2–12)	<0.001
CRP (mg/dL)	0.67 (0.14–1.79)	0.03 (0.01–0.15)	<0.001
BMI (kg/m^2)	22.5 [20.1–24.8]
Disease duration (months)	16 [4–81]
Current smoker	16/112 (14.3)
66 swollen joint count	4 [1–9]
68 tender joint count	3 [0–8]
28 swollen joint count	2 [0–6]
28 tender joint count	2 [0–5.3]
DAS28-ESR	4.08 [2.88–5.09]
RF positivity	102 (79.1)
Anti-CCP positivity	112/126 (88.9)
Comorbidities
Osteoporosis	16 (12.3)
Hypertension	22 (16.9)
Diabetes mellitus	6 (4.6)
Dyslipidemia	6 (4.6)
Hypothyroidism	7 (5.4)
Chronic hepatitis B	3 (2.3)
Baseline modified SHS	3.5 [0–18]
Erosion	1 [0–9]
Joint space narrowing	2 [0–9]
Duration between baseline and follow-up X-ray (months)	20.5 [13–27]
Follow-up modified SHS	6 [1–23]
Erosion	3 [0–13]
Joint space narrowing	2 [0–11]
SHS change/year	0.21 [0–1.95]

Values are expressed as the median [IQR 25–75%] or (%) unless stated otherwise. RA: rheumatoid arthritis; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; BMI: body mass index; DAS28: disease activity score 28; anti-CCP: anticyclic citrullinated peptide; SHS: Sharp/van der Heijde score.