Predictive Value of Two Polymorphisms of ERCC2, rs13181 and rs1799793, in Clinical Outcomes of Chemotherapy in Gastric Cancer Patients: A Meta-Analysis

Table 3

Meta-analysis of the association between ERCC2 rs13181 polymorphism and chemotherapy in objective response rate and overall survival for gastric cancer patients.

Genetic comparisons	Subgroup analysis	No. of studies	Test of association			Model	Test of heterogeneity
			OR/HR (95% CI)					(%)
Objective response rate (OR)
CC vs. AA	Total ethnicity	7	1.01 (0.61–1.68)	0.04	0.968	R	0.003	69.30	0.892
	Caucasian	2	1.16 (0.26–5.27)	0.20	0.845	R	0.004	88.20
	Asian	5	1.00 (0.58–1.74)	0.00	0.997	R	0.047	58.50
AC vs. AA	Total ethnicity	7	1.06 (0.83–1.37)	0.47	0.641	R	0.143	37.40	0.517
	Caucasian	2	1.06 (0.70–1.61)	0.28	0.783	R	0.290	10.70
	Asian	5	1.04 (0.74–1.46)	0.25	0.806	R	0.077	52.60
CC + AC vs. AA	Total ethnicity	10	1.07 (0.84–1.36)	0.52	0.600	R	0.017	55.40	0.661
	Caucasian	2	1.07 (0.48–2.39)	0.17	0.866	R	0.040	76.30
	Asian	8	1.08 (0.83–1.41)	0.58	0.562	R	0.037	53.20
CC vs. AA + AC	Total ethnicity	7	0.98 (0.65–1.46)	0.12	0.907	R	0.031	56.70	0.760
	Caucasian	2	1.06 (0.31–3.66)	0.09	0.925	R	0.006	86.70
	Asian	5	1.02 (0.70–1.50)	0.12	0.907	F	0.270	22.60
Overall survival (HR)
CC vs. AA	Asian	5	0.99 (0.72–1.36)	0.09	0.928	F	0.185	35.4	0.739
AC vs. AA	Asian	5	1.01 (0.78–1.30)	0.07	0.947	F	0.468	0	0.651
CC + AC vs. AA	Asian	6	1.28 (0.85–1.91)	1.18	0.238	R	0.073	50.4	0.814

OR: odds ratio; HR: hazard ratio; CI: confidence interval; vs.: versus; F: fixed effect model; R: random effect model.