Plasma Heme Oxygenase-1 Levels in Patients with Coronary and Peripheral Artery Diseases
Table 1
Clinical characteristics and plasma HO-1 levels of patients with and without CAD.
CAD(−) ()
value CAD(−) versus CAD
CAD(+) ()
1-VD ()
2-VD ()
3-VD ()
value among 4 groups
Age (years)
65 ± 12
<0.001
70 ± 9
68 ± 10
68 ± 10
73 ± 7
<0.001
Gender (male)
121 (65%)
<0.005
170 (76%)
68 (75%)
46 (70%)
56 (82%)
<0.025
Hypertension
116 (63%)
<0.001
180 (80%)
70 (77%)
52 (79%)
58 (85%)
<0.05
SBP (mmHg)
131 ± 21
NS
133 ± 21
133 ± 21
139 ± 21
130 ± 24
NS
Diabetes mellitus
25 (14%)
<0.001
81 (36%)
27 (30%)
26 (39%)
28 (41%)
<0.001
Smoking
59 (32%)
<0.01
99 (44%)
43 (47%)
28 (42%)
28 (41%)
<0.05
Hyperlipidemia
74 (40%)
<0.001
132 (59%)
50 (55%)
41 (62%)
41 (60%)
<0.001
Statin
46 (25%)
<0.001
105 (47%)
39 (43%)
31 (47%)
35 (51%)
<0.001
LDL-C (mg/dL)
112 ± 30
NS
114 ± 32
111 ± 34
117 ± 32
116 ± 29
NS
HDL-C (mg/dL)
59 ± 15
<0.001
51 ± 13
54 ± 14
49 ± 11
49 ± 12
<0.001
HO-1 levels
0.35
NS
0.44
0.45
0.41
0.43
NS
(ng/mL)
[0.25, 0.53]
[0.25, 0.59]
[0.27, 0.63]
[0.25, 0.56]
[0.19, 0.55]
HO-1 < 0.35 ng/mL
91 (49%)
NS
89 (40%)
32 (35%)
27 (41%)
30 (44%)
NS
PAD (ABI < 0.9)
3 (2%)
<0.001
33 (15%)
9 (10%)
5 (8%)
19 (28%)
<0.001
Aspirin
59 (32%)
<0.001
130 (58%)
50 (55%)
44 (67%)
36 (53%)
<0.001
Data represent the mean ± SD or the number (%) of patients, with the exception of HO-1 level which is presented as the median value and interquartile range. SBP: systolic blood pressure; LDL-C: low-density lipoprotein cholesterol; and HDL-C: high-density lipoprotein cholesterol.
