Research Article
DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases
Table 1
Study population characteristics.
| | Parameter | Cases | Controls | value |
| | Anthropometric | | Age (years) | | | <0.0001 | | Gender (M/F) | | | 0.0677 | | Weight (kg) | | | 0.9245 | | Waist (cm) | | | 0.0523 | | Hip (cm) | | | 0.4631 | | BMI (kg/m2) | | | 0.5621 | | Risk factors | | Smoking | 24.5% | 28% | 0.2750 | | Diabetes | 67.3% | — | | Type of CVD and intervention | | Coronary and peripheral artery disease | 65.0% | — | | | Heart failure | 22.0% | — | | Stroke | 10% | — | | Coronary artery bypass graft | 3% | — | | Medication | | Statins | 54% | — | | | Antiplatelets | 13% | — | | β-Blockers | 7% | — | | Blood pressure treatment | 50% | — | | Blood pressure | | SBP (mmHg) | | | 0.0046 | | DBP (mmHg) | | | 0.3431 | | Metabolic markers | | FBG (mmol/l) | | | <0.0001 | | HbA1c (%) | | | <0.0001 | | TC (mmol/l) | | | 0.0002 | | TG (mmol/l) | | | 0.0350 | | HDL (mmol/l) | | | 0.0207 | | LDL (mmol/l) | | | <0.0001 | | Circulating inflammatory markers | | DUSP1 (ng/ml) | 27.85 (11.25-139.08) | 25.14 (0.33-68.65) | 0.0203 | | hsCRP (mg/l) | 3.12 (0.09-11.85) | 2.37 (0.20-10.50) | 0.0426 | | oxLDL (μg/l) | 16.0 (0.03-61.21) | 18.6 (5.19-60.25) | 0.0003 |
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Data are presented as mean ± SD. value shows the differences between cases and controls. BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; FBG: fasting blood glucose; HbA1c: hemoglobin A1c; TC: total cholesterol; TG: triglycerides; HDL: high-density lipoprotein; LDL: low-density lipoprotein; CVD: cardiovascular disease; DUSP1: dual-specificity phosphatase 1; hsCRP: high-sensitivity C-reactive protein; oxLDL: oxidized low-density lipoprotein. |
