Prognostic Factors and Nomograms to Predict Overall and Cancer-Specific Survival for Children with Wilms’ Tumor

Table 3

Multivariate Cox’s regression analysis for OS and CSS in Wilms’ tumor patients from the training cohort.

Variables	Overall survival			Cancer-specific survival
	HR	95% CI		HR	95% CI
Age
≤3	Reference			Reference
3-18	1.745	1.206-2.524	0.003	2.155	1.442-3.220	<0.001
Laterality
Left	Reference			Reference
Right	0.783	0.538-1.141	0.203	0.747	0.497-1.121	0.158
Bilateral	1.887	1.036-3.435	0.038	2.263	1.221-4.195	0.009
Tumor size
≤4	Reference			Reference
4-7	2.991	1.117-8.010	0.029	3.622	1.044-12.566	0.043
>7	1.832	0.733-4.581	0.195	2.534	0.790-8.131	0.118
Surgical status
No	Reference			Reference
Yes	0.376	0.183-0.771	0.008	0.405	0.182-0.901	0.027
SEER historic stage A
Regional	Reference			Reference
Localized	0.728	0.443-1.194	0.209	0.527	0.302-0.919	0.024
Distant	2.307	1.482-3.589	<0.001	2.134	1.358-3.353	0.001