Molecular Composition of Genomic TMPRSS2-ERG Rearrangements in Prostate Cancer

Figure 1

(a) Upper panel: sectional map of chromosome 21:39,500,000–43,000,000 showing all genes (gray boxes), including ERG and TMPRSS2. Middle and lower panels: genomic organization of the TMPRSS2 and ERG genes and their corresponding breakpoint cluster regions, respectively. Vertical bars above the breakpoint cluster regions represent individual genomic breakpoints for the 58 patients with prostate cancer: black line, fusion sequence identified in the present study; orange line, fusion sequence reported in the literature [29–32]. Results of Kernel density analysis are illustrated above the middle and lower panels: black line, breakpoint density; gray line, lower limit of 95% confidence interval, determined using a bootstrapping procedure; dashed line, 95% confidence interval of a density function resulting from simulations at randomly distributed pseudo-breakpoints. (b) Correlation between breakpoint localization within breakpoint cluster regions of TMPRSS2 and ERG, respectively, and age at diagnosis. (c) Correlation between breakpoint localization within breakpoint cluster regions of TMPRSS2 and ERG, respectively, and Gleason score.

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