Overexpression of eIF3D in Lung Adenocarcinoma Is a New Independent Prognostic Marker of Poor Survival

Figure 4

Copy number alterations and DNA methylation analysis of eIF3D in LUAD patients. (a) Heatmap showing eIF3D expression and corresponding DNA copy number alterations, averaged DNA methylation, and methylation in cg14297023. (b) Plot chart showing eIF3D expression in different CNA groups. (c) Linear regression analysis of the correlation between eIF3D expression and its linear copy number values. (d) Kaplan-Meier survival analysis of different eIF3D CNA levels for OS in patients with LUAD. (e) Plot chart showing DNA methylation of cg14297023 site in LUAD tissues and adjacent normal tissues. (f) Linear regression analysis of the correlation between cg14297023 methylation and eIF3D expression. (g) Kaplan-Meier survival analysis of different methylation levels in cg14297023 for OS in patients with LUAD. Adj. N: adjacent normal tissues; GISTIC: Genomic Identification of Significant Targets in Cancer [25].

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