Genetic Association between NFKBIA and NFKB1 Gene Polymorphisms and the Susceptibility to Head and Neck Cancer: A Meta-Analysis

Table 2

Results of overall and subgroup analyses for gene polymorphisms (rs28362491 and rs2233406).

rs28362491	No	D versus I			DD versus II			DI versus II			DD+DI versus II			DD versus DI+II
		OR	95% CI		OR	(95% CI)		OR	(95% CI)		OR	(95% CI)		OR	(95% CI)
Overall	9	0.89	0.79-1.00	0.059	0.76	0.60-0.97	0.026	0.95	0.82-1.08	0.419	0.89	0.76-1.05	0.165	0.80	0.68-0.95	0.010
PCR-RFLP	2	1.04	0.89-1.22	0.630	0.96	0.65-1.40	0.813	1.17	0.93-1.48	0.179	1.13	0.91-1.41	0.274	0.88	0.62-1.26	0.495
PCR-PAGE	2	0.74	0.61-0.91	0.004	0.57	0.38-0.85	0.007	0.73	0.53-1.02	0.063	0.67	0.49-0.92	0.012	0.69	0.49-0.98	0.039
TaqMan	3	0.79	0.69-0.91	0.001	0.61	0.45-0.83	0.002	0.83	0.69-1.00	0.047	0.75	0.60-0.94	0.014	0.70	0.60-0.83	<0.001
OC	3	0.86	0.58-1.27	0.457	0.73	0.32-1.65	0.446	0.82	0.56-1.20	0.314	0.79	0.46-1.33	0.369	0.84	0.49-1.46	0.543
HNC	2	1.04	0.88-1.22	0.630	0.96	0.65-1.40	0.813	1.17	0.93-1.48	0.179	1.13	0.91-1.41	0.274	0.88	0.62-1.26	0.495
NC	4	0.87	0.78-0.96	0.007	0.75	0.62-0.90	0.002	0.94	0.81-1.09	0.400	0.87	0.74-1.02	0.096	0.78	0.68-0.89	<0.001
rs2233406	No	T versus C			TT versus CC			TC versus CC			TT+TC versus CC			TT versus CC+TC
		OR	95% CI		OR	(95% CI)		OR	(95% CI)		OR	(95% CI)		OR	(95% CI)
Overall	4	1.13	0.90-1.42	0.296	1.51	0.99-2.30	0.058	1.08	0.85-1.39	0.523	1.12	0.86-1.44	0.399	1.50	0.98-2.29	0.061
TaqMan	2	1.25	0.72-2.16	0.431	1.68	0.93-3.04	0.084	1.19	0.66-2.12	0.565	1.23	0.68-2.23	0.497	1.67	0.92-3.02	0.089
OC	2	1.39	0.97-1.98	0.074	1.92	0.93-3.98	0.080	1.36	0.99-1.88	0.059	1.40	0.98-2.00	0.062	1.81	0.87-3.75	0.111
NC	2	0.96	0.83-1.10	0.520	1.33	0.79-2.24	0.290	0.90	0.77-1.05	0.180	0.92	0.79-1.07	0.296	1.36	0.81-2.29	0.251